Nicotinamide is a form of Vitamin B3 that may preserve and improve beta cell function. It has been used in diabetes treatment and prevention. Potential side effects include headache, skin and GI effects, exacerbation of gout and ulcers, as well as allergies. Liver and platelet function should be monitored. It may increase serum concentrations of the anticonvulsants, carbamazepine and primidone. A large population-based trial in New Zealand was conducted in high risk children. Islet cell antibodies (ICA) were measured in over 20,000 children. A total of 185 children had positive ICA levels indicating a higher risk for development of diabetes. Of these; 173 children received nicotinamide for an average follow up time of 7.1 years. Nicotinamide use decreased the incidence of diabetes by 60%. Another trial, the Deutsche Nicotinamide Intervention Study (DENIS), in 55 children at high risk for type 1 diabetes showed no major decrease of diabetes. The role of nicotinamide is unknown at this time and more may be known when the ENDIT (European Nicotinamide Diabetes Intervention Trial) is published.
Complementary and Alternative Medicine Pages:
Main | Concerns | Gymnema Sylvestre | Fenugreek | Bitter Melon | Ginseng | Nopal | Aloe, Bilberry, and Milk Thistle | Chromium | Vanadium | CoQ10 | Nicotinamide | Alpha Lipoic Acid | Gamma Linolenic Acid | Ginkgo Biloba | Garlic | Advice | Additional Reading | References
Laura Shane-McWhorter, PharmD, BCPS, FASCP, CDE, BC-ADM
November 24, 2001
Last Updated: Wednesday December 31, 2014 20:55:33
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents.
© Children with Diabetes, Inc. 1995-2016. Comments and Feedback.