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Current Research News

    19 July 2017

  1. [New!] Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.
  2. [New!] Assessing the effectiveness of a 3-month day-and-night home closed-loop control combined with pump suspend feature compared with sensor-augmented pump therapy in youths and adults with suboptimally controlled type 1 diabetes: a randomised parallel study protocol. Free full text available in HTML and PDF formats.
  3. [New!] Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes.
  4. [New!] Nasal Glucagon Fixes Severe Hypoglycemia in Type 1 Diabetes.

    12 July 2017

  5. My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety.
  6. Occupation with grain crops is associated with lower type 1 diabetes incidence: Registry-based case-control study. Free full text available in PDF format.
  7. Overnight Closed Loop Control Improves Glycemic Control in a Multicenter Study of Adults with Type 1 Diabetes.
  8. The Challenges of Achieving Postprandial Glucose Control using Closed-Loop Systems in Patients with Type 1 Diabetes.
  9. Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children. See also Type 1 diabetes risk linked to intestinal viruses.

    28 June 2017

  10. Extensive Assessment of Blood Glucose Monitoring During Postprandial Period and Its Impact on Closed-Loop Performance.
  11. Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.
  12. Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene Expression. Free full text available in HTML and PDF formats.
  13. β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”. Free full text available in HTML and PDF formats.

    21 June 2017

  14. Oral insulin therapy fails to prevent type 1 diabetes, but some see disease delay.
  15. Racial and ethnic differences among children with new-onset autoimmune Type 1 diabetes.
  16. Retinal Ganglion Cell Loss in Children With Type 1 Diabetes Mellitus Without Diabetic Retinopathy.
  17. Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity.

    14 June 2017

  18. Stability, Accuracy, and Risk Assessment of a Novel Subcutaneous Glucose Sensor.
  19. Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.
  20. Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.

    7 June 2017

  21. Bioengineering of an Intraabdominal Endocrine Pancreas. Free full text available in PDF format.
  22. 'Artificial Pancreas' Coming Soon for Diabetes Patients.
  23. Closed-Loop Insulin Delivery for Adults with Type 1 Diabetes Undertaking High-Intensity Interval Exercise Versus Moderate-Intensity Exercise: A Randomized, Crossover Study.
  24. Analyzing breath samples of hypoglycemic events in type 1 diabetes patients: towards developing an alternative to diabetes alert dogs.
  25. Clinical Impact of Blood Glucose Monitoring Accuracy: An In-Silico Study.

    31 May 2017

  26. Effect of artificial pancreas systems on glycaemic control in patients with type 1 diabetes: a systematic review and meta-analysis of outpatient randomised controlled trials.
  27. "It is Definitely a Game Changer": A Qualitative Study of Experiences with In-home Overnight Closed-Loop Technology Among Adults with Type 1 Diabetes.
  28. Mortality in type 1 diabetes diagnosed in childhood in Northern Ireland during 1989-2012: A population-based cohort study.
  29. Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.
  30. Markers of immune-mediated inflammation in the brains of young adults and adolescents with type 1 diabetes and fatal diabetic ketoacidosis. Is there a difference?
  31. Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

    24 May 2017

  32. Development of glucose-responsive 'smart' insulin systems.
  33. Impact of age and antibody type on progression from single to multiple autoantibodies in type 1 diabetes relatives.
  34. Sodium-Glucose Co-transporter-2 Inhibitors and Diabetic Ketoacidosis. An Updated Review of the Literature.

    17 May 2017

  35. Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts.
  36. A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach.
  37. Study: Artificial pancreas helps young children better control their diabetes.
  38. The Impact of Diet Wheat Source on the Onset of Type 1 Diabetes Mellitus-Lessons Learned from the Non-Obese Diabetic (NOD) Mouse Model. Free full text available in HTML and PDF formats.
  39. Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline.
  40. Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.
  41. A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes.

    10 May 2017

  42. Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity.
  43. Intraperitoneal Insulin Delivery Provides Superior Glycemic Regulation to Subcutaneous Insulin Delivery in Model Predictive Control-based Fully-automated Artificial Pancreas in Patients with Type 1 Diabetes: A Pilot Study.
  44. Behavioral Patterns and Associations with Glucose Control During 12-Week Randomized Free-Living Clinical Trial of Day and Night Hybrid Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes.
  45. Heterogeneity of Type 1 Diabetes: The Effect of Ethnicity.

    3 May 2017

  46. Dog Exposure During the First Year of Life and Type 1 Diabetes in Childhood. See also Man's Best Friend Fails to Protect Against Type 1 Diabetes.
  47. Outpatient Closed-Loop Control with Unannounced Moderate Exercise in Adolescents Using Zone Model Predictive Control.
  48. Closed-Loop Control of Postprandial Glycemia Using an Insulin-on-Board Limitation Through Continuous Action on Glucose Target.
  49. A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes. Free full text available in HTML and PDF formats. See also Predictive tool for children with type 1 diabetes will improve care, avoid complications.
  50. Endocannabinoid system acts as a regulator of immune homeostasis in the gut. Free full text available in HTML and PDF formats. See also Compound in marijuana, chili peppers could reduce gut inflammation in type 1 diabetes.
  51. Circulating unmethylated insulin DNA as a potential non-invasive biomarker of beta cell death in type 1 Diabetes: a review and future prospect. Free full text available in HTML and PDF formats.

    26 April 2017

  52. Can Type 1 diabetes progression be halted? Possible role of high dose vitamin D and omega 3 fatty acids.
  53. Performance of an Artificial Pancreas System for Young Children with Type 1 Diabetes.
  54. Effects of Dapagliflozin on Insulin-requirement, Glucose Excretion, and ß- Hydroxybutyrate levels are not related to Baseline HbA1c in Youth with Type 1 Diabetes.
  55. Psychiatric medication use before and after the onset of type 1 diabetes in children and adolescents: A population-based cohort study.
  56. Xenotransplantation of layer-by-layer encapsulated non-human primate islets with a specified immunosuppressive drug protocol.

    19 April 2017

  57. Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012.
  58. Ethnic differences in association of high body mass index with early onset of Type 1 diabetes – Arab ethnicity as case study. Free full text available in HTML and PDF formats.
  59. Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes.
  60. Rotavirus Vaccination and the Risk of Celiac Disease or Type 1 Diabetes in Finnish Children at Early Life.
  61. Metabolomics reveals new metabolic perturbations in children with type 1 diabetes.
  62. Low-calorie sweeteners may allow more glucose to enter fat cells.

    12 April 2017

  63. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. See also ‘Medicinal food’ diet counters onset of type 1 diabetes.
  64. Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). Free full text available in HTML and PDF formats.
  65. Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C-peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial.
  66. Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets. See also New source of insulin-producing cells discovered for diabetics, A Brand New Type of Insulin-Producing Cell Has Been Discovered Hiding in the Pancreas, and New type of insulin-producing cell discovered.
  67. Single Retinal Layer Evaluation in Patients with Type 1 Diabetes with No or Early Signs of Diabetic Retinopathy: The First Hint of Neurovascular Crosstalk Damage between Neurons and Capillaries?

    29 March 2017

  68. Worm infestations and development of autoimmunity in children - The ABIS study. Free full text available in HTML and PDF formats.
  69. Duodenal mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota.
  70. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.
  71. Monogenic Diabetes accounts for 6.3% of cases referred to 15 Italian pediatric diabetes Centers during 2007-2012.
  72. Biomarker found that could help predict the onset of Type 1 diabetes.

    22 March 2017

  73. Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes. Free full text available in HTML and PDF formats.
  74. An analysis of the survival outcomes of simultaneous pancreas and kidney transplantation compared to live donor kidney transplantation in patients with type 1 diabetes: a UK Transplant Registry study.

    15 March 2017

  75. Vaccinations in early life are not associated with development of islet autoimmunity in type 1 diabetes high-risk children: Results from prospective cohort data.
  76. Use of Wearable Sensors and Biometric Variables in an Artificial Pancreas System. Free full text available in HTML and PDF formats.
  77. Meal Detection and Carbohydrate Estimation Using Continuous Glucose Sensor Data.
  78. Single-donor islet transplantation in type 1 diabetes: patient selection and special considerations. Free full text available in HTML and PDF formats.
  79. Association of Skin Intrinsic Fluorescence with Retinal Microvascular Complications of Long Term Type 1 Diabetes in the Wisconsin Epidemiologic Study of Diabetic Retinopathy.
  80. CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success? Free full text available in HTML and PDF formats.

    8 March 2017

  81. Updated 24-year trend of Type 1 diabetes incidence in children in Poland reveals a sinusoidal pattern and sustained increase.
  82. Using in vivo corneal confocal microscopy to identify diabetic sensorimotor polyneuropathy risk profiles in patients with type 1 diabetes. Free full text available in HTML and PDF formats.
  83. Leptin Levels in Patients with Type 1 Diabetes Mellitus After Fetal Pancreatic Stem Cell Transplant.

    1 March 2017

  84. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Free full text available in HTML and PDF formats. See also Fasting diet 'regenerates diabetic pancreas'.
  85. Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes. See also City of Hope researchers discover new potential cause of type 1 diabetes and and New Theory About the Cause of Type 1 Diabetes.
  86. An Amperometric Glucose Sensor Integrated Into an Insulin Delivery Cannula: In Vitro and In Vivo Evaluation. Free full text available in HTML and PDF formats.
  87. Pleotropic Acute and Chronic Effects of Leptin to Reverse Type 1 Diabetes.

    22 February 2017

  88. Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes.
  89. Intralymphatic Injection of Autoantigen in Type 1 Diabetes. See also Injection Into Lymph Nodes May Slow Progression of Type 1 Diabetes.
  90. Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis. Free full text available in HTML and PDF formats.
  91. Early microvascular retinal changes in optical coherence tomography angiography in patients with type 1 diabetes mellitus.
  92. Efficacy and Safety of Metreleptin Therapy in Patients With Type 1 Diabetes: A Pilot Study.

    15 February 2017

  93. Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes. Free full text available in HTML and PDF formats.
  94. The Use of Electrochemiluminescence Assays to Predict Autoantibody and Glycemic Progression Toward Type 1 Diabetes in Individuals with Single Autoantibodies.

    8 February 2017

  95. Faster-acting insulin aspart provides faster onset and greater early exposure vs insulin aspart in children and adolescents with type 1 diabetes mellitus.
  96. In-vitro evaluation of enteric coated insulin tablets containing absorption enhancer and enzyme inhibitor.

    1 February 2017

  97. Psychosocial effects in parents and children 12 years after newborn genetic screening for type 1 diabetes.
  98. Increase in Pancreatic Proinsulin and Preservation of Beta Cell Mass in Autoantibody Positive Donors prior to Type 1 Diabetes Onset.
  99. Glucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 Diabetes.
  100. Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls.
  101. Interspecies organogenesis generates autologous functional islets. See also Rat-grown mouse pancreases help reverse diabetes in mice.

    25 January 2017

  102. Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study. Free full text available in HTML and PDF formats. See also New artificial pancreas study shows blood sugar improvements in type 1 diabetes.
  103. Outpatient 60-hour day-and-night glucose control with dual-hormone artificial pancreas, single-hormone artificial pancreas, or sensor-augmented pump therapy in adults with type 1 diabetes: an open-label, randomised, crossover, controlled trial.
  104. Predictive Hyperglycemia and Hypoglycemia Minimization: In-Home Evaluation of Safety, Feasibility, and Efficacy in Overnight Glucose Control in Type 1 Diabetes.
  105. Continuous Glucose Monitoring Enables the Detection of Losses in Infusion Set Actuation (LISAs). Free full text available in HTML and PDF formats.
  106. Pro-inflammatory Effects of Hypoglycemia in Humans with or without Diabetes.

    18 January 2017

  107. Predictive Hyperglycemia and Hypoglycemia Minimization: In-Home Evaluation of Safety, Feasibility, and Efficacy in Overnight Glucose Control in Type 1 Diabetes.
  108. First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study.
  109. Diet Quality during Infancy and Early Childhood in Children with and without Risk of Type 1 Diabetes: A DEDIPAC Study. Free full text available in HTML and PDF via link.
  110. Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept.

    11 January 2017

  111. Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.
  112. Improved Postprandial Glycemic Control with Faster-Acting Insulin Aspart in Patients with Type 1 Diabetes Using Continuous Subcutaneous Insulin Infusion.
  113. Is islet transplantation a realistic approach to curing diabetes? Free full text available in HTML and PDF formats.
  114. "Learning" Can Improve the Blood Glucose Control Performance for Type 1 Diabetes Mellitus.
  115. Role of intestinal microbiota and metabolites on gut homeostasis and human diseases. Free full text available in HTML and PDF formats.

    4 January 2017

  116. Bionic pancreas system successfully controls blood sugar without risk of hypoglycemia reports on Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover tria, previously reported.
  117. Four-year clinical remission of type 1 diabetes mellitus in two patients treated with sitagliptin and vitamin D3. Free full text available in HTML and PDF formats.
  118. The influence of sex on hyperfiltration in patients with uncomplicated type 1 diabetes.
  119. Extending Halogen-based Medicinal Chemistry to Proteins. See also Chemically modified insulin is available more quickly.
  120. Harvard biologist retracts diabetes breakthrough in Cell. See also Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation.

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Last Updated: Wednesday July 19, 2017 18:45:30
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