Back to Ask the Diabetes Team Ask the Diabetes Team

From a physician:

My patient develops hives to NPH, but not Regular. So far we have been premedicating him with Benadryl [an antihistamine]. Have you found other creative solutions other than Lente and Ultralente? Could it be the preservatives?


As you imply, there's probably something in the NPH that could be responsible for the allergic reaction: usually, it's thought to be the Protamine. Things to try:

  1. Switch from NPH to Lente. They have approximately the same effect and approximately the same duration of action, and a unit-for-unit switch may solve the problem.

  2. Switch from Lilly brand to Novo-Nordisk, or from Novo-Nordisk to Lilly. There's the remote chance it's something in the buffers that might be different between the two different manufacturers.

  3. Call the manufacturers and ask their advice: their phone numbers are in the PDR (Physician's Desk Reference).


Original posting 18 Feb 97


  Back to Ask the Diabetes Team Return to the Top of This Page

Last Updated: Tuesday April 06, 2010 15:08:54
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.