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From Michigan, USA:

Is there any reason not to use Humalog and NPH under certain circumstances in conjunction with a basic regimen built on the use of Ultra Lente and Regular?


There is rarely a reason not to try a combination of different insulins if you are willing to spend the time to figure out when the insulins are truly working (as opposed to when they are supposed to be working) and when they overlap.

One important point however, is that you cannot mix NPH insulin and either Lente or Ultralente in the same syringe, as NPH and the Lente insulins (Lente and Ultralente) are chemically incompatible. They can be given in separate syringes at the same time at separate injections sites.

Why not use Lente instead of NPH? The time of action is similar. I have patients mixing lispro insulin [Humalog®], Regular, Lente, and Ultralente in the same syringe (very difficult at times to figure out when each insulin starts and stops.)

Most importantly, be sure to discuss your plans with your own physician before making any major change.


Original posting 29 Mar 97


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Last Updated: Tuesday April 06, 2010 15:08:54
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