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It has been advocated that the interval between giving Regular insulin and eating should vary depending on the preprandial glucose level to allow time for the glucose to fall to normal levels before "adding" glucose with the meal. I have seen no such recommendations with the use of lispro, but the same logic would seem to hold. For example: if the preprandial glucose is 200, and one is using lispro, shouldn't one still wait some period of time before eating to allow for the lispro to reduce the current level to the recommended 70-130 range? Thanks.


You are quite correct in what you say about timing the administration of conventional Regular insulin, but the same rationale does not apply to lispro insulin [Humalog®]. The new substituted insulin usually begins to act within about ten minutes so clearly there is a risk of hypoglycemia if eating is delayed. The great advantage though is that Lispro can be given immediately after the meal and in this way the dose can be adjusted both for the pre-meal blood sugar level and for appetite.


Original posting 29 Mar 97


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Last Updated: Tuesday April 06, 2010 15:08:54
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