From Huntsville, Texas, USA:
Reports from Sweden and US (rat studies) seem to indicate that C-peptide and insulin reduce vascular and neural dysfunction in diabetics. Is this combination being used anywhere regularly or in clinical studies anywhere, and if so, where? I am parent of 32 year old Type 1 diabetic who has had it for 24 years.
Not long ago there was an article by Thomas Maugh 11, a science writer with the L.A. Times, reporting some studies from Washington University in St. Louis, Missouri, which had showed that in chemically induced diabetic rats microvascular and neurological complications could be both prevented and alleviated by supplementing insulin with C-peptide, the other fraction of pro-insulin (Ido.Y. et al., Science, Vol 277, page 563, July 1997). The actions of C-peptide were not simply a reversal of the diabetic process; but were mediated through quite different mechanisms. However the difficulty of transposing this work to humans was that rats do not have the same susceptibility to retinal disease that humans do.
Nonetheless, the Eli Lilly Co. sponsored an initial clinical trial with the help of Dr. Julio Santiago at the same University. Unhappily he recently died and as far as I can tell no formal report of the work has been published, although a preliminary account showed no effect when achieving normal levels of C-peptide. No one at this center knew of any other clinical trials nor are there any references in MEDLINE.
My guess would be that the preliminary results in man did not offer prospects that were any improvement on current regimens. If and when trials resume, I would not be too optimistic that they would offer much to your 32 year old beyond what good control can do.
Original posting 26 Sep 97
Last Updated: Tuesday April 06, 2010 15:08:54
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.