From Hugo, Minnesota, USA:
I would like to know the current status of the TRIGR trial, and any other primary prevention trials. Have results been published from this trial regarding the relationship between cow's milk and the development of type 1 diabetes?
The role of early exposure to cow's milk in the pathogenesis of typeá1A (autoimmune) is still controversial. In the DAISY study no effect was found. In the Finnish Trial to Reduce IDDM in the Genetically at Risk Study (TRIGR) there were differences in antibody response to bovine insulin during the first year of life; but no change in T-cell response. This study is reported in the October 2000 issue of the journal Diabetes.
There are other studies which are still much more positive about such a link including some that suggest that the trigger lies in a fragment of a specific cow's milk protein which is not present in all species thus explaining some of the variability of results.
The two main secondary prevention trials ENDIT using nicotinamide and DPT-1 using insulin are just nearing the end of their course and no results have yet been published though other studies have shown that nicotinamide can defer insulin dependance in about 60% of new onset cases. I know of no completed trials of primary prevention though with the recent hugely increased understanding of the basis of autoimmunity. These are beginning.
Original posting 2 May 2001
Posted to Research: Causes and Prevention
|Return to the Top of This Page|
Last Updated: Tuesday April 06, 2010 15:09:22
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.