From Meskanaw, Saskatchewan, Canada:
I am a 30 year old female who has had type 1 diabetes for 23 years, and my doctor recently prescribed metformin for my insulin resistance. It works great, however, the side effects such as heartburn and bloating are bothersome. My pharmacist suggested that Avandia would be the next drug of choice. Does Avandia work the same as metformin? Have there been any studies done on the effects of metformin and Avandia in type 1 diabetes?
Studies have been done with both agents in typeá1 diabetes. However, their effects on lowering blood sugar are modest when you are already on insulin. As you would expect, most of the studies have been performed on patients with typeá2 diabetes.
There have been a number of patients who have been identified as having type 1 diabetes but who also have the genetics/family history of type 2, diabetes, making them insulin resistant. The biggest problem with Avandia and the drugs in that class is a propensity to cause weight gain, whereas metformin does not induce weight gain. It may help to cut the dose of metformin back and work up slowly.
Any changes you make should be discussed with your physician.
|Return to the Top of This Page|
Last Updated: Tuesday April 06, 2010 15:09:30
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.