Back to Ask the Diabetes Team Ask the Diabetes Team

From a healthcare professional in Iola, Kansas, USA:

I have a 35 year old, overweight female patient who was diagnosed with type 1 diabetes and he is now requiring 76 units of insulin per day. So, I believe that she must have insulin resistance and am wondering if I should start thiazolidinediones. Could you please explain the mechanism of insulin resistance in type 1 diabetes? Does she have the same risk factors for complications as some with type 2 and metabolic syndrome?


The difference between type 1 and type 2 diabetes is becoming more difficult as we see more and more patients with signs and symptoms that are found in both types of diabetes. The onset at age 33 is relatively old for a patient with type 1, however possible. Type 1 diabetes would have been characterized by DKA [diabetic ketoacidosis], insulinopenia, or the presence of anti-GAD, anti-islet cell or anti-insulin antibodies.

There are patients with type 1 diabetes who have marked insulin resistance. They usually have a family history of diabetes. That means they have the genetic predisposition to type 2 diabetes but need to give the insulin they would otherwise not make. The risks and complications are probably similar, especially when the sugars are not controlled. However, there may be even more large blood vessel disease in patients with type 2 diabetes.


Original posting 23 Sep 2002
Posted to Other


  Back to Ask the Diabetes Team Return to the Top of This Page

Last Updated: Tuesday April 06, 2010 15:09:38
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.