Back to Ask the Diabetes Team Ask the Diabetes Team

From Baltimore, Maryland, USA:

My three year old daughter has just begun pump therapy, and her pediatric endocrinologist wants her to be on U-50 NovoLog, but the manufacturer has not done any studies on mixing U-100 NovoLog with any of their three diluents and is hesitant (to say the least) to recommend any of them. The endocrinologist wants us to stick with NovoLog because we know NovoLog. We can predict her blood sugars almost flawlessly. We have given 110% of the last year to learning how her body responds to this insulin and really don't want to start all over with Humalog.

Are you familiar with using U-50-NovoLog in a pump? If so, are you aware of any problems that may have surfaced? Are potential risks associated with using an unstudied diluent/insulin mixture mild, moderate or dangerous? Worst case scenario: we can't get U-50 NovoLog or we see problems arise, what next? Do we even have a choice?


I have no experience with U-50 NovoLog but have managed many young children on insulin pumps with undiluted insulin. You may want to check with your daughter's endocrinologist to see if diluting the insulin is absolutely necessary. Many pumps will do 0.05 unit/hour increments in basal rate, and it is also possible to set the pump to do "0" unit per hour basals if lower average basals are needed.


Original posting 16 Mar 2003
Posted to Insulin Analogs and Insulin Pumps


  Back to Ask the Diabetes Team Return to the Top of This Page

Last Updated: Tuesday April 06, 2010 15:09:42
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.