Is it true that impaired glucose, due to obesity (weight 100 kg [220 pounds]), can neither have beta cells dysfunction/damage nor low insulin production but a problem of insulin utilization? Are there pathology tests to confirm that beta cells are in order and insulin production is also in order? Can this situation can be reversed by reducing weight?
Impaired glucose tolerance is associated with decreased insulin response in the target tissues. In addition, even as blood glucose levels become mildly elevated, it has been noted that there is also inappropriate insulin secretion for the degree of elevated glucose. Losing weight will help improve the target tissues' response to the insulin and improve glucose utilization. However, not all people who are heavy have diabetes. They appear to be able to compensate for the insulin resistance by increasing insulin secretion. It appears there are genetic determinants that mark people for the development of diabetes that are not clearly understood. If individuals are at risk for developing diabetes or if they have pre-diabetes, it is very important to lose excess weight and exercise regularly.
|Return to the Top of This Page|
Last Updated: Tuesday April 06, 2010 15:10:00
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.