From Wayland, Massachusetts, USA:
I am curious to know how many people with type 1 diabetes are positive for the autoantibodies that, when triggered, cause the autoimmune attack on the beta cells. Do you have to have the HLA gene in addition to the autoantibodies? If one does not have the autoantibodies, does this mean that other causes such as viral or trauma are the cause? Are these routine laboratory tests or do you have to request that they are done?
About 60 to 80% of type 1 diabetes patients will be positive for one of the islet cell antibodies when done in research laboratories. Nothing is known when such tests are done with commercial laboratories. Negative tests just mean negative tests and do not imply lack of autoimmunity. Whether a virus or other environmental factors are the triggers is also not related to antibody status. There are some strong associations and links with different patterns of islet cell antibodies, but they are difficult to utilize for any individual, more useful with large studies looking for broad association and correlations. There is not much reason to do routine islet cell antibody testing in newly diagnosed type 1 diabetes unless part of a research study looking for causes since it does not help much with treatment decisions. If there is some question, of what type of diabetes a person has, then antibody status may imply earlier use and need of insulin.
Original posting 21 Feb 2006
Posted to Research: Causes and Prevention
|Return to the Top of This Page|
Last Updated: Tuesday April 06, 2010 15:10:06
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.