Back to Ask the Diabetes Team Ask the Diabetes Team

From Lubbock, Texas, USA:

My three-year-old daughter was diagnosed with type 1 diabetes at the age of nine months. She is currently on an insulin pump and CGMS. She was tested for Kir6.2 and was negative.

My question is related to hypoglycemia and sulfa drugs. My daughter was put on Bactrim in September for a minor infection and it caused her to have severe lows daily. Her blood glucose still spiked after meals, but she was so sensitive to insulin that she would plummet into hypoglycemia within an hour of eating and she had repeated lows at night in spite of her CGMS. We stopped the medication after three days and her numbers and insulin sensitivity returned to normal.

We recently started her on Celebrex for JRA (Juvenile Rheumatoid Arthritis) and it contains sulfa. For the first 10 days, her numbers were much better than normal with an average of about 140 mg/dl [7.8 mmol/L]. I was surprised, but assumed that her lack of pain and inflammation was causing the better numbers. However, we are now starting to see the same kind of insulin sensitivity issues and lows at night. I have been reducing her basals daily and watching her numbers closely, but she's still dropping into the 40s mg/dl [2.2 to 2.7 mmol/L] at least once and into the 60s mg/dl [3.3 to 3.8 mmol/L] several times daily. The drops are so sudden that the CGMS can't even prevent them before they reach this level. The lows also take much longer to respond to glucose than normal.

We see endocrinologists at the Barbara Davis Center in Denver and even they are unsure about what's happening. Any insight or experience you have in this area would be greatly appreciated.


I have not heard of this. I do not think that the sulfonyurea drugs, which are used as oral hypoglycemic agents are the same thing as sulfa containing antibiotics, though.


Original posting 16 Dec 2007
Posted to Hypoglycemia and Other Medications


  Back to Ask the Diabetes Team Return to the Top of This Page

Last Updated: Tuesday April 06, 2010 15:10:16
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.