Back to Ask the Diabetes Team Ask the Diabetes Team

From India:

I read the following about actions of insulin at Wikipedia: "Increased potassium uptake - forces cells to absorb serum potassium; lack of insulin inhibits absorption." And, "Arterial muscle tone - forces arterial wall muscle to relax, increasing blood flow, especially in micro arteries; lack of insulin reduces flow by allowing these muscles to contract."

So, can continual and increased insulin cause decreased urine exposure by changing some muscular tone in urinary system? It is obvious that if insulin lowers glucose levels, urine excretion can also be decreased. But I want to know its impact on changing muscular tone directly or indirectly. If insulin can cause decreased urine excretion, can creatnine clearance be effected due to it? I commonly feel such resistance in normal urine passage, on increasing insulin and reversal on decreasing it.


The effect of filtered glucose outweighs all effects of insulin on the microcirculation in the kidney. In other words, if glucose levels go above 200 mg/dl [11.1 mmol/L] exceeding the ability of the kidney to reabsorb glucose, insulin does not have the capacity to change things that much in the small vessels. Remember also that hyperglycemia is associated with hyperfiltration and changes in creatinine clearance.


Original posting 1 Jun 2008
Posted to Other and Insulin


  Back to Ask the Diabetes Team Return to the Top of This Page

Last Updated: Tuesday April 06, 2010 15:10:16
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.

This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.