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Research News From 2006

    31 December 2006

  1. Autonomic Nerve Testing Predicts the Development of Complications.
  2. Signs of ß-Cell Autoimmunity in Nondiabetic Schoolchildren: A comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate.
  3. Glycemic Thresholds for Activation of Counterregulatory Hormone and Symptom Responses in Islet Transplant Recipients.
  4. Bedside neuropathy disability score compared to quantitative sensory testing for measurement of diabetic neuropathy in children, adolescents, and young adults with type 1 diabetes.
  5. Subclinical Coronary and Aortic Atherosclerosis Detected by Magnetic Resonance Imaging in Type 1 Diabetes With and Without Diabetic Nephropathy.
  6. Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year.
  7. Increasing the Accuracy of Oral Glucose Tolerance Testing and Extending Its Application to Individuals With Normal Glucose Tolerance for the Prediction of Type 1 Diabetes: The Diabetes Prevention Trial-Type 1.
  8. Skin Autofluorescence Is a Strong Predictor of Cardiac Mortality in Diabetes.
  9. The changing spectrum of diabetes in Mexican American youth.
  10. Cortisol Secretion in Patients With Type 2 Diabetes: Relationship with chronic complications.

    24 December 2006

  11. Extreme genetic risk for type 1A diabetes, previously reported, now has free full text available in HTML and PDF formats.
  12. Progress in the development of immune-based therapies for type 1 diabetes mellitus.
  13. Prolonged Remission of Diabetes by Regeneration of beta Cells in Diabetic Mice Treated with Recombinant Adenoviral Vector Expressing Glucagon-like Peptide-1.
  14. Islet transplantation for type 1 diabetes—where should we go? Also available in PDF format.
  15. Insulin-independence is rarely sustained after pancreatic islet transplantation. Also available in PDF format.
  16. Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia.
  17. The human lens' transparence changes in children, adolescents, and young adults with diabetes mellitus type I.
  18. Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell.
  19. Comparison of Plasma Insulin Levels after a Mixed Meal Challenge in Children with and without Intrauterine Exposure to Diabetes. Free full text available in PDF format.
  20. Adenoviral-Mediated Overexpression of Membrane-Bound Human FasL and Human Decoy Fas Protect Pig Islets Against Human CD8(+) CTL-Mediated Cytotoxicity.
  21. 17 December 2006

  22. TRPV1+ Sensory Neurons Control ß Cell Stress and Islet Inflammation in Autoimmune Diabetes. Free full text available in HTML and PDF formats. See also Diabetes breakthrough; Toronto scientists cure disease in mice, Nervous system appears to play key role in developing Type 1 diabetes, Scientists make diabetes breakthrough in mice, and Type 1 Diabetes May Be Caused By Disruption of Link Between Nerve Cells and Beta Cells.
  23. Immune-neuroendocrine interactions and autoimmune diseases.
  24. Intranasal insulin administration: A method for dissociating central and peripheral effects of insulin.
  25. Children Diagnosed with Diabetes during Infancy Have Unique Clinical Characteristics.
  26. Insulin resistance in children and adolescents.

    10 December 2006

  27. Central Obesity, Incident Microalbuminuria, and Change in Creatinine Clearance in the Epidemiology of Diabetes Interventions and Complications Study concludes that "... waist circumference predicts the subsequent development of microalbuminuria in type 1 diabetes."
  28. Predicting the Development of Macrovascular Disease in People with Type 1 Diabetes: A 9-Year Follow-up Study.
  29. Cardiovascular Risk Factors Predicting the Development of Distal Symmetrical Polyneuropathy in People with Type 1 Diabetes: A 9-Year Follow-up Study.
  30. Diabetic Neuropathy Differs in Type 1 and Type 2 Diabetes.
  31. Pancreatic autoantibodies in Italian patients with newly diagnosed type 1 diabetes mellitus over the age of 20 years.
  32. Inflammatory Process in Type 2 Diabetes: The Role of Cytokines.
  33. A Potent Immunomodulatory Compound, VGX-1027, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice.
  34. Research Yields New Insights Into The Cause Of Diabetes.

    3 December 2006

  35. Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes.
  36. Continuous glucose monitoring and external insulin pump: towards a subcutaneous closed loop.
  37. The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.
  38. Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo.
  39. Protection from type 1 diabetes by vitamin d receptor haplotypes.
  40. Immunointervention in newly diagnosed type 1 diabetes.
  41. DiaPep277(R) Preserves Endogenous Insulin Production by Immunomodulation in Type 1 Diabetes.
  42. HLA Class I Epitope Discovery in Type 1 Diabetes.
  43. Effects of Autoimmunity and Immune Therapy on ß-Cell Turnover in Type 1 Diabetes.
  44. Is it dietary insulin?
  45. Viruses cause type 1 diabetes in animals.
  46. Immunomodulation for the Prevention of SPIDDM and LADA.
  47. Insulin Treatment in Patients With Type 1 Diabetes Induces Upregulation of Regulatory T-Cell Markers in Peripheral Blood Mononuclear Cells Stimulated With Insulin In Vitro.
  48. Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome.
  49. Early Involvement of the Spinal Cord in Diabetic Peripheral Neuropathy.
  50. Skin Autofluorescence as a Noninvasive Marker of Vascular Damage in Patients With Type 2 Diabetes.
  51. C-Peptide Reverses Nociceptive Neuropathy in Type 1 Diabetes.
  52. Cord Blood Islet Autoantibodies Are Related to Stress in the Mother during Pregnancy.
  53. Recovery of Islet ß-Cell Function in Streptozotocin- Induced Diabetic Mice; An Indirect Role for the Spleen.
  54. Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction.
  55. Plasma C-Peptide and Cognitive Performance in Older Men Without Diabetes.

    26 November 2006

  56. New data from NIH lab confirms protocol to reverse type 1 diabetes in mice. However, see also Comment on Papers by Chong et al., Nishio et al., and Suri et al. on Diabetes Reversal in NOD Mice (PDF), Response to Comment on Chong et al. on Diabetes Reversal in NOD Mice (PDF), Response to Comment on Nishio et al. on Diabetes Reversal in NOD Mice (PDF), and Response to Comment on Suri et al. on Diabetes Reversal in NOD Mice (PDF).
  57. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Free full text available in PDF format. See also Human Bone Marrow Cells Repair Mouse Islets.
  58. Elevated serum alanine transaminase in patients with type 1 or type 2 diabetes mellitus.
  59. Elevated circulating adiponectin in type 1 diabetes is associated with long diabetes duration.
  60. Plasma homocysteine, oxidative stress and endothelial function in patients with Type 1 diabetes mellitus and microalbuminuria.
  61. Divergent trends in the incidence of end-stage renal disease due to Type 1 and Type 2 diabetes in Europe, Canada and Australia during 1998-2002.
  62. Pasteur-Weizmann/Servier prize winners advance diabetes therapy R&D.
  63. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study.
  64. Treatment of new-onset type 1 diabetes with peptide DiaPep277(R) is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial.
  65. Suppression of diabetes in non-obese diabetic (NOD) mice by oral administration of a cholera toxin B subunit-insulin B chain fusion protein vaccine produced in silkworm.
  66. Renoprotective effects of tea catechin in streptozotocin-induced diabetic rats.
  67. Luminance and chromatic visual evoked potentials in type I and type II diabetes: relationships with peripheral neuropathy.

    19 November 2006

  68. Evidence for immunological priming and increased frequency of CD4(+) CD25(+) cord blood T cells in children born to mothers with type 1 diabetes.
  69. Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials.
  70. Viral infections as potential triggers of type 1 diabetes.
  71. Diabetes mellitus and dementia.

    12 November 2006

  72. QT(c) interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up.
  73. Parental reactions to information about increased genetic risk of type 1 diabetes mellitus in infants.
  74. Seasonality of birth in children and young adults (0-29 years) with type 1 diabetes in Ukraine.
  75. The immunity during the pre-clinical period of type I diabetes mellitus.
  76. Patterns of growth among children who later develop type 2 diabetes or its risk factors.
  77. Association of amino-terminal-specific anti-glutamate decarboxylase (GAD65) autoantibodies with beta cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis prone diabetes mellitus. Free full text available in PDF format.

    5 November 2006

  78. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS).
  79. Maternal understanding of infant diabetes risk: Differential effects of maternal anxiety and depression.
  80. Metabolic factors affecting residual Beta cell function assessed by C-Peptide secretion in patients with newly diagnosed type 1 diabetes.
  81. Markers of absorption and synthesis of cholesterol in men with type 1 diabetes.
  82. Glucose-monitoring with continuous subcutaneous microdialysis in neonatal diabetes mellitus.
  83. Fuzzy-based controller for glucose regulation in type-1 diabetic patients by subcutaneous route.
  84. Partial versus Full Allogeneic Hemopoietic Chimerization Is a Preferential Means to Inhibit Type 1 Diabetes as the Latter Induces Generalized Immunosuppression.

    29 October 2006

  85. Does Coffee Consumption Reduce the Risk of Type 2 Diabetes in Individuals With Impaired Glucose?
  86. Incidence of Type 1 Diabetes in Philadelphia Is Higher in Black Than White Children From 1995 to 1999 - Epidemic or misclassification?
  87. Islet Autoimmunity in Children With Down’s Syndrome.
  88. Evaluation of a New Measure of Blood Glucose Variability in Diabetes.
  89. A multinational assessment of complications in type 1 diabetes: the DiaMond substudy of complications (DiaComp) level 1.
  90. Electrogastrography in children and adolescents with type 1 diabetes: Weak correlation with metabolic control parameters.
  91. Relationship between adiponectin levels, acylated ghrelin levels, and short-term body mass index changes in children with diabetes mellitus type 1 at diagnosis and after insulin therapy.
  92. Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers.
  93. Health Care Use and Costs in the Decade After Identification of Type 1 and Type 2 Diabetes.

    22 October 2006

  94. Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).
  95. Putting the pieces of the puzzle together - a series of hypotheses on the etiology and pathogenesis of type 1 diabetes.
  96. A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease.
  97. Islet antibodies associated with pancreatic B-cell dysfunction at and 3 years after diagnosis of diabetes in subjects aged 35–64 years old: degree of impairment less severe than in those aged 0–34 years old.
  98. Usefulness of colour tissue Doppler imaging in assessing aortic elastic properties in Type 1 diabetic patients.
  99. Mother to child transmission of diabetes mellitus: does gestational diabetes program Type 2 diabetes in the next generation?
  100. Postchallenge glucose rises with increasing age even when glucose tolerance is normal.

    15 October 2006

  101. Advances and Emerging Opportunities in Type 1 Diabetes Research will guide NIH research into type 1 diabetes. See also Plan Will Guide NIH Research in Type 1 Diabetes.
  102. Increased intestinal permeability precedes clinical onset of type 1 diabetes.
  103. Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus.
  104. Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes.
  105. Attitudes of genetic counselors towards expanding newborn screening and offering predictive genetic testing to children.
  106. Prevalence of Glutamic Acid Decarboxylase Antibody Positivity and its Association with Insulin Secretion and Sensitivity in Autoimmune Thyroid Disease: A Pilot Study.
  107. Five Weeks of Treatment with the GLP-1 Analogue Liraglutide Improves Glycaemic Control and Lowers Body weight in Subjects with Type 2 Diabetes.
  108. Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis.

    8 October 2006

  109. The Burden of Diabetes Mellitus Among US Youth: Prevalence Estimates From the SEARCH for Diabetes in Youth Study. See also Study Finds One in 523 Children and Adolescents Have Diabetes.
  110. ABC News has two online videos about the recent study published in The New England Journal of Medicine (International Trial of the Edmonton Protocol for Islet Transplantation): Summary of the Study and Interview with Dr. Camillo Ricordi from the DRI.
  111. Therapy with the hsp60 peptide DiaPep277(TM) in C-peptide positive type 1 diabetes patients. See also The Swedish GAD-vaccination Trial: Outcomes of a Phase II Safety and Efficacy Trial with Diamyd(TM) for Preservation of Beta Cell Function in Children with Type 1 Diabetes.
  112. Dietary insulin as an immunogen and tolerogen.
  113. Is affluence a risk factor for bronchial asthma and type 1 diabetes?
  114. Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives.
  115. Role of seasonal factors in pre- and postnatal ontogenesis for etiology of type 1 diabetes mellitus.
  116. Short-term suppression of elevated growth hormone concentrations following insulin-like growth factor 1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates.
  117. Is arterial hyepertension a significant problem in children and adolescents with type 1 diabetes?
  118. Diabetes mellitus and risk of bladder cancer: a meta-analysis.
  119. Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q.
  120. Beverage Intake Among Preschool Children and Its Effect on Weight Status. Free full text available in HTML and PDF formats.

    1 October 2006

  121. International Trial of the Edmonton Protocol for Islet Transplantation reviews the history of islet cell transplantation and concludes that "... insulin independence is usually not sustainable." See also Diabetes Treatment Disappoints in New Study.
  122. Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects.
  123. Cholesterol Absorption and Synthesis in Children With Type 1 Diabetes.
  124. Paradoxically enhanced heart tolerance to ischaemia in type 1 diabetes and role of increased osmolarity.
  125. Oxidative stress markers in plasma and urine of prepubertal patients with type 1 diabetes mellitus.
  126. Modeling Chronic Glycemic Exposure Variables as Correlates and Predictors of Microvascular Complications of Diabetes.
  127. Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: The effect of improved glycemic control.
  128. Clinical characteristics and diabetes associated autoantibodies in patients with both type 1 diabetes mellitus and asthma.
  129. Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus.
  130. Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double-blind controlled trials.
  131. Vitamin E and Risk of Type 2 Diabetes in the Women’s Health Study Randomized Controlled Trial.
  132. Smoking enhances absorption of insulin but reduces glucodynamic effects in individuals using the Lilly-Dura inhaled insulin system.

    24 September 2006

  133. The Politics and Promise of Stem-Cell Research is an editorial published in the September 21, 2006 issue of The New England Journal of Medicine. Also available in PDF format. See also Bit Player or Powerhouse? China and Stem-Cell Research, also available in PDF format; Stem cells--a clinical update which has free full text available in PDF format; and Naturally dead embryos yield stem cells.
  134. Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells.
  135. Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice.
  136. A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report.
  137. Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor.
  138. Early epitope- and isotype-specific humoral immune responses to GAD65 in young children with genetic susceptibility to type 1 diabetes.
  139. Effects of treatment for diabetes mellitus on circulating vascular progenitor cells.
  140. Total and Component Health Care Costs in a Non-Medicare HMO Population of Patients With and Without Type 2 Diabetes and With and Without Macrovascular Disease.
  141. Relationship Between Lipid Abnormalities and Insulin Resistance in Japanese School Children.
  142. Study Suggests Insulin May Have Potential to Prevent Thrombosis Leading to Heart Attack and Stroke. See also Insulin for heart attacks.

    17 September 2006

  143. Switching from Insulin to Oral Sulfonylureas in Patients with Diabetes Due to Kir6.2 Mutations. See also Activating Mutations in the ABCC8 Gene in Neonatal Diabetes Mellitus, Drug Restores Insulin Secretion for Rare Type 1 Cases, and Molecular medicine comes to the rescue: Targeted therapy turns life around for child with neonatal diabetes. Parents of children who were diagnosed before 6 months of age should speak with their diabetes team about this research.
  144. Effect of Ramipril on the Incidence of Diabetes. The DREAM Trial Investigators. Full text available in PDF format. See also Angiotensin-Converting–Enzyme Inhibitors for Impaired Glucose Tolerance — Is There Still Hope?, EASD: ACE-Inhibitor Diabetes Prevention DREAM is Over, and Drug Can Prevent Diabetes in Many at High Risk, Study Suggests.
  145. Abstracts are available from the just completed EASD meeting.
  146. MRI Can Track Survival Of Pancreatic Islets After Transplantation.
  147. Extreme genetic risk for type 1A diabetes. Full text available in PDF format.
  148. Seasonal variation in the diagnosis of type 1 diabetes in south-east Sweden.
  149. Induction of the chemokine interferon-gamma-inducible protein-10 in human pancreatic islets during enterovirus infection.
  150. Circulating antibodies to nephrin in patients with type 1 diabetes.
  151. The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.
  152. Iodine status, thyroid function, thyroid volume and thyroid autoimmunity in patients with type 1 diabetes mellitus in an iodine-replete area.
  153. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice.
  154. Selective susceptibility of different populations of sympathetic neurons to diabetic neuropathy in vivo is reflected by increased vulnerability to oxidative stress in vitro.
  155. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. Full text available in HTML and PDF formats.
  156. Little evidence for early programming of weight and insulin resistance for contemporary children: EarlyBird Diabetes Study report 19.
  157. Liraglutide, A Once-daily GLP-1 Analogue, Shows Potential To Change Course Of [Type 2] Diabetes.

    10 September 2006

  158. Researchers Uncover Gene That Raises Risk for Type 1 Diabetes.
  159. Extrapancreatic Proinsulin/Insulin-expressing Cells in Diabetes Mellitus: Is History Repeating Itself?
  160. Effects of a vitamin D(3) analog on diabetes in the bio breeding (BB) rat.
  161. Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes.
  162. Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes.
  163. Treatment burden and health-related quality of life of children with diabetes, cystic fibrosis and asthma.
  164. Glucose abnormalities in a 14-year old patient treated with a second generation antipsychotic. A case study.

    3 September 2006

  165. A screening system for detecting genetic risk markers of type 1 diabetes in dried blood spots.
  166. Secondary prevention of type 1 diabetes mellitus: stopping immune destruction and promoting beta-cell regeneration. Full text available in HTML and PDF formats.
  167. Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes.
  168. Development of microvascular complications in type 1 diabetic patients 10 years follow-up.
  169. Risk factors of diabetic nephropathy progression in patients with a long history of diabetic mellitus as shown by a retrospective analysis.
  170. Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes.
  171. Coronary artery calcification, serum lipids, lipoproteins, and peripheral inflammatory markers in adolescents and young adults with type 1 diabetes.
  172. Epidemiology of type 1 diabetes in children and adolescents aged less than 15 years in the provinces of Castilla y Leon (Spain).
  173. Influence of osmolytes on in vivo glucose monitoring using optical coherence tomography.

    27 August 2006

  174. Drug Insight: new immunomodulatory therapies in type 1 diabetes.
  175. C-Peptide Does Not Affect Ocular Blood Flow in Patients With Type 1 Diabetes.
  176. Natural History and Risk Factors for Microalbuminuria in Adolescents With Type 1 Diabetes.
  177. Oesophageal motility disorders in type 1 diabetes mellitus and their relation to cardiovascular autonomic neuropathy.
  178. Decline in Neurophysiological Function After 7 Years in an Adolescent Diabetic Cohort and the Role of Aldose Reductase Gene Polymorphisms.
  179. The visceral and subcutaneous fat changes in type 1 diabetes: a pilot study.
  180. Apolipoprotein B as a long-term predictor of mortality in type 1 diabetes mellitus: a 15-year follow up. See also Apolipoprotein B at the Wikipedia.
  181. Benfotiamine Prevents Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress Following a Meal Rich in Advanced Glycation End Products in Individuals With Type 2 Diabetes.
  182. Treating Postprandial Hyperglycemia Does Not Appear to Delay Progression of Early Type 2 Diabetes.
  183. Effect of Weight Loss With Lifestyle Intervention on Risk of [Type 2] Diabetes.
  184. Diabetes, Inflammation, and Functional Decline in Older Adults.
  185. Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes.
  186. In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets.
  187. A patient with severe, recurrent hypoglycemia and glycemic lability who underwent islet transplantation.
  188. Control oriented model of insulin and glucose dynamics in type 1 diabetics.
  189. Dysfunction of the vitamin D endocrine system as common cause for multiple malignant and other chronic diseases.

    20 August 2006

  190. Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999.
  191. Diabetes preventive gluten-free diet decreases the number of caecal bacteria in non-obese diabetic mice.
  192. Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association Studies.
  193. Early Manifestation of Type 1 Diabetes in Children Is a Risk Factor for Changed Bone Geometry: Data Using Peripheral Quantitative Computed Tomography.
  194. Effects of aspirin plus alpha-tocopherol on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus.
  195. Possible effect of leptin on renal magnesium excretion in adolescent patients with type 1 diabetes.
  196. The effects of calcitriol and nicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes (IMDIAB XI).
  197. Model-based blood glucose control for Type 1 diabetes via parametric programming.
  198. Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.

    13 August 2006

  199. Vascular endothelial and smooth muscle function relate to body mass index and glucose in obese and non-obese children. Full text available in PDF format.
  200. Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes. Full text available in PDF format.
  201. Evaluation of the left ventricular hemodynamic function and myocardial perfusion by gated single photon emission tomography, in patients with type 1 diabetes mellitus; prodromal signs of cardiovascular disease after four years.
  202. Polymorphism I/D of the angiotensin-converting enzyme gene and disturbance of blood prssure in type 1 diabetic children and adolescents.
  203. Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes.
  204. Liver stem cell-derived beta-cell surrogates for treatment of type 1 diabetes.
  205. Emerging Science Note/Sugar Blues is an audio presentation about diabetes and depression.

    6 August 2006

  206. Rotavirus-specific T cell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes.
  207. Costimulation couture: a designer approach to regulating autoimmunity. Full text available in HTML and PDF formats.
  208. Current status of pancreatic islet transplantation.
  209. Prevalence of EGG Derangement in Newly Diagnosed Type 1 Diabetes in Childhood.
  210. Iron-binding antioxidant capacity is impaired in diabetes mellitus.
  211. Cellular basis of diabetic nephropathy: IV Antioxidant enzyme mRNA expression levels in skin fibroblasts of type 1 diabetic sibling pairs.
  212. TIME magazine reports on Stem Cells: The Hope And The Hype.

    30 July 2006

  213. Higher incidence of childhood-onset type 1 diabetes mellitus in remote areas: a UK regional small-area analysis.
  214. Negative association between occurrence of type 1 diabetes and tuberculosis incidence at population level.
  215. Relationship between nitrogen oxide and the degree of metabolic control of diabetes mellitus type 1 in children and adolescents.
  216. Characterization of pancreatic stem cells derived from adult human pancreas ducts by fluorescence activated cell sorting.
  217. Intrahepatic Transplanted Islets in Humans Secrete Insulin in a Coordinate Pulsatile Manner Directly Into the Liver.

    23 July 2006

  218. A Significant Role for Histocompatibility in Human Islet Transplantation.
  219. Type 1 diabetes: pathogenesis and prevention. Free full text available in PDF format and includes excellent drawings that help explain the autoimmune process of type 1 diabetes.
  220. Effects of vitamin D receptor gene polymorphisms on susceptibility to type 1 diabetes mellitus.
  221. C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats.
  222. Lower bone mineral content in children with type 1 diabetes mellitus is linked to female sex, low IGFI levels and high insulin requirement. Free full text available in PDF format.
  223. Homocysteinylation of low-density lipoproteins (LDL) from subjects with Type 1 diabetes: effect on oxidative damage of human endothelial cells.
  224. N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination.
  225. Dietary proteins as environmental modifiers of type 1 diabetes mellitus.
  226. Growth disorders in children with type 1 diabetes mellitus.
  227. Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes.
  228. Villous histomorphometry and placental bed biopsy investigation in Type I diabetic pregnancies.

    16 July 2006

  229. Paratuberculosis and Type I diabetes Is this the trigger?
  230. Is facilitating pancreatic beta cell regeneration a valid option for clinical therapy?
  231. Left ventricular chamber and myocardial systolic function reserve in patients with type 1 diabetes mellitus: insight from traditional and Doppler tissue imaging echocardiography.
  232. Retinal Vascular Caliber and Risk of Retinopathy in Young Patients with Type 1 Diabetes.
  233. Raised C-reactive protein levels in patients with recent onset type 1 diabetes.
  234. Increased syndecan-1 in serum is related to early nephropathy in type 1 diabetes mellitus patients.
  235. Type 1 diabetes and multiple sclerosis: a Danish population-based cohort study.
  236. A novel drug delivery system for type 1 diabetes: Insulin-mimetic vanadyl-poly(gamma-glutamic acid) complex. See also Bis(allixinato)oxovanadium(IV) complex is a potent antidiabetic agent: studies on structure-activity relationship for a series of hydroxypyrone-vanadium complexes.

    9 July 2006

  237. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
  238. Insulin resistance in type 1 diabetic children and adolescents - a simplified method of estimation.
  239. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?
  240. Preliminary data on monosymptomatic nocturnal enuresis in children and adolescents with type 1 diabetes.
  241. Birth weight and type 1 diabetes among schoolchildren in Taiwan-A population-based case-controlled study.
  242. Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
  243. UF study sheds light on cystic fibrosis-related diabetes. An audio presentation is also available.

    2 July 2006

  244. The Effect of Glucose Variability on the Risk of Microvascular Complications in Type 1 Diabetes concludes "... that blood glucose variability does not appear to be an additional factor in the development of microvascular complications." Free full text available in HTML and PDF formats.
  245. Embryonic Pig Pancreatic Tissue Transplantation for the Treatment of Diabetes. Free full text available in HTML and PDF formats.
  246. Suitability of human juvenile pancreatic islets for clinical use.
  247. Combination therapy reverses type 1 diabetes in animals. Free full text of the study -- -- is available in HTML and PDF formats.
  248. Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes.
  249. Evaluation of the Effect of Gain on the Meal Response of an Automated Closed-Loop Insulin Delivery System.
  250. C-peptide replacement improves weight gain and renal function in diabetic rats.
  251. Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. See also Diabetes Adds 15 Years to Heart Attack Risk Calculation.
  252. A Strong Dose-Response Relation Between Serum Concentrations of Persistent Organic Pollutants and Diabetes - Results from the National Health and Examination Survey 1999–2002.
  253. A Prospective Study of Dairy Intake and the Risk of Type 2 Diabetes in Women.
  254. Ethnicity, Obesity, and Risk of Type 2 Diabetes in Women.
  255. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.
  256. The Unitarian Hypothesis for the aetiology of diabetes mellitus.
  257. Diabetes, insulin, and risk of cancer.

    25 June 2006

  258. Association between infectious diseases and type 1 diabetes: a case-crossover study.
  259. HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.
  260. Does physiological beta cell turnover initiate autoimmune diabetes in the regional lymph nodes?
  261. Assessing 1-h plasma glucose and shape of the glucose curve during oral glucose tolerance test.
  262. Hyperketonemia (ketosis), oxidative stress and type 1 diabetes.
  263. Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes. Free full text available in HTML and PDF formats. The PDF version includes an excellent diagram of the physiological and behavioral defenses against hypoglycemia. See also Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia- induced hormonal counterregulation, which also has free full text available in HTML and PDF formats. Repeat Episodes Of Low Blood Sugar Spell Diabetic Disaster offers a brief, non-technical summary.

    18 June 2006

  264. ADA: 50-Year Type 1 Diabetes Survivors Show Islet Cells.
  265. Diabetes mellitus and immunization.
  266. Solitary pancreas transplantation for life-threatening allergy to human insulin.
  267. Early diastolic impairment of diabetic heart: The significance of right ventricle.
  268. Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill children.
  269. Alcohol intake, consumption pattern and beverage type, and the risk of Type 2 diabetes.

    11 June 2006

  270. Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin.
  271. Stem cell sources for clinical islet transplantation in type 1 diabetes: Embryonic and adult stem cells.
  272. Parameters favouring successful adult pig islet isolations for xenotransplantation in pig-to-primate models.
  273. Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept.
  274. A Newly Developed Bioartificial Pancreas Successfully Controls Blood Glucose in Totally Pancreatectomized Diabetic Pigs.
  275. Thyroid autoimmunity in children with coexisting type 1 diabetes mellitus and celiac disease: a multicenter study.
  276. Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development.

    4 June 2006

  277. 30-year Study Of Type 1 Diabetes Finds No Improvement In Heart Disease Rates helps explain The 30-Year Natural History of Type 1 Diabetes Complications; The Pittsburgh Epidemiology of Diabetes Complications Study Experience, previously reported.
  278. Assessment of glycemic control after islet transplantation using the continuous glucose monitor in insulin-independent versus insulin-requiring type 1 diabetes subjects.
  279. Lower-than-Expected Prevalence and Severity of Retinopathy in an Incident Cohort followed during the First 4-14 Years of Type 1 Diabetes.
  280. Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes.
  281. Plasma homocysteine levels in children and adolescents with type 1 diabetes.
  282. Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.
  283. Thiamine (Vitamin B(1)) Improves Endothelium-Dependent Vasodilatation in the Presence of Hyperglycemia.

    28 May 2006

  284. Trends in diabetes mellitus among privately insured children, 1998-2002.
  285. Effect of nicotinamide on newly diagnosed type 1 diabetic children.
  286. Cognitive Performance, Psychological Well-Being, and Brain Magnetic Resonance Imaging in Older Patients With Type 1 Diabetes.
  287. Reversal of Type 1 Diabetes by Engineering a Glucose Sensor in Skeletal Muscle.
  288. Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells.
  289. Investigation of the age-at-onset heterogeneity in type 1 diabetes through mathematical modeling.
  290. 1,5-Anhydroglucitol and Postprandial Hyperglycemia as Measured by Continuous Glucose Monitoring System in Moderately Controlled Patients With Diabetes.
  291. Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans.
  292. Autoimmune thyropathies in diabetics.
  293. Towards a pro-inflammatory and immunomodulatory emerging role of leptin.
  294. Triamcinolone as adjunctive treatment to laser panretinal photocoagulation for proliferative diabetic retinopathy.

    21 May 2006

  295. Reversal of Diabetes by Pancreatic Islet Transplantation into a Subcutaneous, Neovascularized Device.
  296. Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients.
  297. The restorative effects of pulsed infrared light therapy on significant loss of peripheral protective sensation in patients with long-term type 1 and type 2 diabetes mellitus.
  298. Nicotinamide Reduces High Secretion of IFN-gamma in High-Risk Relatives Even Though It Does Not Prevent Type 1 Diabetes.
  299. Preserved sensitivity to {beta}2-adrenergic receptor agonists in patients with type 1 diabetes mellitus and hypoglycemia unawareness. Free full text available in PDF format.
  300. New Study Reveals Signaling Pathways Required for Expansion of Pancreas Stem Cells. See BMP4 Regulates Pancreatic Progenitor Cell Expansion through Id2.
  301. The association of serum total sialic acid/total protein ratio with diabetic parameters in young type 1 diabetic patients.
  302. The activity of N-acetyl-beta-d-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children.
  303. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.

    14 May 2006

  304. T Cell "Brakes" Lost During Human Evolution.
  305. Progress in islet transplantation in patients with type 1 diabetes mellitus.
  306. Renal transplantation in diabetic patients.
  307. Influence of pancreas and kidney transplant function on recipient survival.
  308. Evaluation of type 1 diabetics for simultaneous pancreas-kidney transplantation with regard to cardiovascular risk.
  309. Regulation of cerebral glucose metabolism.
  310. Changing cerebral blood flow velocity by transcranial Doppler during head up tilt in patients with diabetes mellitus.
  311. Human bone marrow mesenchymal stem cells transfected with human insulin genes can secrete insulin stably.
  312. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure?

    7 May 2006

  313. A cure for type 1 diabetes? references Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs, previously reported. Free full text available in PDF format.
  314. Current indications for pancreas or islet transplant.
  315. Comparison of 1-year patient and graft survival rates between preemptive and dialysed simultaneous pancreas and kidney transplant recipients.
  316. Does familiarity breed acceptance? The influence of policy on physicians' attitudes toward newborn screening programs.
  317. Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes.
  318. Impact of Renin Angiotensin System Modulation on the Hyperfiltration State in Type 1 Diabetes.
  319. An immunologic homunculus for type 1 diabetes. Free full text available in PDF format.
  320. Prevalence of Diabetes and Impaired Fasting Glucose Levels Among US Adolescents: National Health and Nutrition Examination Survey, 1999-2002.
  321. Dermatosis in children with diabetes mellitus.
  322. Muscle adiposity and body fat distribution in type 1 and type 2 diabetes: varying relationships according to diabetes type.
  323. Use of a standardized protocol to decrease medication errors and adverse events related to sliding scale insulin.
  324. Methodology for hypoglycaemia detection based on the processing, analysis and classification of the electroencephalogram.

    30 April 2006

  325. Evidence for an Association Between Type 1 Diabetes and Premature Carotid Atherosclerosis in Childhood.
  326. Soluble vascular cell adhesion molecule-1 and soluble E-selectin are associated with micro- and macrovascular complications in Type 1 diabetic patients.
  327. Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus.
  328. Early supernormal retinal oxygenation response in patients with diabetes.
  329. The 30-Year Natural History of Type 1 Diabetes Complications: The Pittsburgh Epidemiology of Diabetes Complications Study Experience.
  330. A Clinical Screening Tool Identifies Autoimmune Diabetes in Adults.
  331. The Belgrade childhood diabetes study - comparison of children with Type 1 diabetes with their siblings.
  332. Tissue selectivity of insulin detemir action in vivo.
  333. Comparison of type 1, type 2, and atypical ketosis-prone diabetes at 4 years of diabetes duration.
  334. Increased Plasma Amylin in Type 1 Diabetic Patients After Kidney and Pancreas Transplantation.
  335. Differential Transmission of Type 1 Diabetes from Diabetic Fathers and Mothers to Their Offspring.
  336. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes.
  337. Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.
  338. Effect of Donor Age on Function of Isolated Human Islets.
  339. Validation of a screening protocol for identifying low-risk candidates with type 1 diabetes mellitus for kidney with or without pancreas transplantation.
  340. Preemptive versus Nonpreemptive Simultaneous Pancreas-Kidney Transplantation: A Single-Center, Long-Term, Follow-up Study.

    23 April 2006

  341. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. Free full text available in PDF format.
  342. Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies.
  343. Air pollution and type 1 diabetes in children.
  344. Independent effects of socioeconomic status and place of residence on the incidence of childhood type 1 diabetes in Western Australia.
  345. Childhood type 1 diabetes mellitus in Newfoundland and Labrador, Canada.
  346. Free radicals related effects and antioxidants in saliva and serum of adolescents with Type 1 diabetes mellitus.
  347. Arterial wall thickening and stiffening in children and adolescents with type 1 diabetes.
  348. Exaggerated adrenarche and altered cortisol metabolism in Type 1 diabetic children.
  349. Leptin levels and body composition in children and adolescents with type 1 diabetes.
  350. Abnormal response to inotropic stimulation in young asymptomatic type I diabetic patients demonstrated by serial gated myocardial perfusion SPECT imaging.
  351. Prospective and Challenges of Islet Transplantation for the Therapy of Autoimmune Diabetes.
  352. Effect of glucagon-like peptide-1 (7-37) on beta-cell function after islet transplantation in type 1 diabetes.
  353. Effect of Rat-to-Mouse Bioartificial Pancreas Xenotransplantation on Diabetic Renal Damage and Survival.
  354. The comparison of treatment results of type 1 diabetes mellitus complicated by end-stage diabetic nephropathy in patients undergoing simultaneous pancreas and pre-emptive kidney transplantation (SPPkTx) and patients enrolled into the dialysis program--a cohort study.

    16 April 2006

  355. A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement.
  356. Preventive and Therapeutic Potential of p38{alpha} Selective MAPK Inhibitor in NOD Mice with Type 1 Diabetes. Free full text available in PDF format.
  357. Islet neogenesis: a potential therapeutic tool in type 1 diabetes.
  358. Dietary Proteins as Environmental Modifiers of Type 1 Diabetes Mellitus.
  359. Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol.
  360. Targeting type 1 diabetes before and at the clinical onset of disease.
  361. Prevalence and clinical characteristics of insulin-treated, anti-GAD-positive, type 2 diabetic subjects in an outpatient clinical department of a Dutch teaching hospital. Free full text available in PDF format.
  362. Early detection of endothelial injury and dysfunction in conjunction with correction of hemodynamic maladjustment can effectively restore renal function in type 2 diabetic nephropathy.
  363. Changes in renal hemodynamics in streptozotocin-induced diabetic rats with L-ascorbic acid supplementation.
  364. Severe depletion of intraepidermal nerve fibers in skin biopsies of pancreas transplant recipients.

    9 April 2006

  365. Information About the Latest Research Findings on Type 1 Diabetes Published in the Journal Science. See also Infused Spleen Cells Found Not to Impact Islet Recovery and Reversal of Type 1 Diabetes in Mice and Diabetes Studies Conflict on Power of Spleen Cells.
  366. Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes.
  367. Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children.
  368. Aminoguanidine prevented impairment of blood antioxidant system in insulin-dependent diabetic rats.
  369. Production of islet-like structures from neonatal porcine pancreatic tissue in suspension bioreactors.
  370. Aetiological heterogeneity of asymptomatic hyperglycaemia in children and adolescents.
  371. Role of the angiotensin II type 1 receptor in the pathogenesis of diabetic retinopathy: effects of blood pressure control and beyond.
  372. Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats.
  373. Intranasal Vaccination with Proinsulin DNA Induces Regulatory CD4+ T Cells That Prevent Experimental Autoimmune Diabetes.
  374. Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo.
  375. B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes.
  376. Insulin independence of unstable diabetic patient after single living donor islet transplantation.
  377. Surgical complications of simultaneous pancreas-kidney transplantation: a 16-year-experience at one center.
  378. Quality of life after simultaneous pancreas-kidney transplantation.
  379. Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study. Free full text available in PDF format.
  380. Preventing diabetes in patients with hypertension: one more reason to block the renin-angiotensin system.
  381. Cost implications of development of diabetes in the ALPINE study.

    2 April 2006

  382. Cognitive and Neural Hippocampal Effects of Long-Term Moderate Recurrent Hypoglycemia.
  383. Therapy of diabetes mellitus : Pancreas transplantation, islet transplantation, stem cell and gene therapy.
  384. Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic ß-Cell Fate.
  385. Decreased In Vitro Type 1 Immune Response Against Coxsackie Virus B4 in Children With Type 1 Diabetes.
  386. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes.
  387. Identical twins discordant for type 1 diabetes show a different pattern of in vitro CD56(+) cell activation.
  388. Insulin Sensitivity, Glucose Effectiveness, and Free Fatty Acid Dynamics Following Human Islet Transplantation for Type 1 Diabetes. Free full text available in PDF format.
  389. Type 1 diabetes in Japan.
  390. Maternal age at delivery and order of birth are risk factors for type 1 diabetes mellitus in Upper Silesia, Poland.
  391. Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.
  392. Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: a nationwide population-based study.
  393. Sympathetic skin responses in Type-1 diabetic children: Relationship to urodynamic findings.
  394. Inhibition of diabetic nephropathy in rats by an oral antidiabetic material extracted from yeast.
  395. Modeling, identification and nonlinear model predictive control of type I diabetic patient.
  396. Type 2 Diabetes in Children and Adolescents - The Next Epidemic?

    26 March 2006

  397. The 24 March 2006 issue of Science contained three reports on studies that sought to replicate the work of Denise Faustman:
    1. Immunological Reversal of Autoimmune Diabetes Without Hematopoietic Replacement of ß Cells.
    2. Reversal of Diabetes in Non-Obese Diabetic Mice Without Spleen Cell-Derived ß Cell Regeneration.
    3. Islet Recovery and Reversal of Murine Type 1 Diabetes in the Absence of Any Infused Spleen Cell Contribution.
  398. For additional news reports on these studies and the work of Denise Faustman, see:
    1. Infused Spleen Cells Found Not To Impact Islet Recovery And Reversal Of Type 1 Diabetes In Mice.
    2. Procedure cures some diabetic mice, but not in the way previously reported.
    3. Researcher 'Elated' Over Failed Diabetes Studies.
    4. A Controversial Therapy for Diabetes Is Verified.
    5. Spleen Cell Treatment Reverses Diabetes in Mice Without Beta Cell Replacement.
    6. Scientists Hold Out Hope for Diabetes Cure.
    7. Study bolsters diabetes attack plan.
  399. Listen to an interview of Dr. Denise Faustman and Dr. David Nathan, professor of medicine; Harvard Medical School; director, General Clinical Research Center, director, Diabetes Center at Massachusetts General Hospital, from NPR, recorded on Friday, March 24, 2006.
  400. More information about Dr. Faustman's work can be found at Type 1 Diabetes Research for Juvenile and Pediatric Diabetes at Mass General Hospital.
  401. Conditional and specific NF-{kappa}B blockade protects pancreatic beta cells from diabetogenic agents.
  402. Space-time clustering analyses of type 1 diabetes among 0- to 29-year-olds in Yorkshire, UK.
  403. Annual incidence of type 1 diabetes in Quebec between 1989-2000 in children.
  404. Nitrate in community water supplies and risk of childhood type 1 diabetes in Sardinia, Italy..
  405. Quality of life after organ transplantation in type 1 diabetics with end-stage renal disease.
  406. A New Strategy Toward Improving Immunoprotection in Cell Therapy for Diabetes Mellitus: Long-Functioning PEGylated Islets In Vivo.

    19 March 2006

  407. Kidney disease rare with early type 1 diabetes onset summarizes Age at Onset of Childhood-Onset Type 1 Diabetes and the Development of End-Stage Renal Disease.
  408. Immune complexes containing modified lipoproteins are related to the progression of internal carotid intima-media thickness in patients with type 1 diabetes.
  409. Growing new endocrine pancreas in situ.
  410. Anti-CD38 autoantibodies in type? diabetes.
  411. Gene therapy for diabetes: reinventing the islet.
  412. Diabetic control after total pancreatectomy.

    12 March 2006

  413. Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial. Free full text available in HTML and PDF formats.
  414. The influence of implantation site on the biocompatibility and survival of alginate encapsulated pig islets in rats.
  415. Non-invasive glucose monitoring in patients with diabetes: A novel system based on impedance spectroscopy.
  416. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. Free full text available in PDF format.
  417. Therapeutic potential of self-antigen-specific CD4(+)CD25(+) regulatory T cells selected in vitro from a polyclonal repertoire.
  418. Photosynthetic Oxygen Generator for Bioartificial Pancreas.
  419. Increased clonogenic potential of circulating endothelial progenitor cells in patients with type 1 diabetes and proliferative retinopathy. Also available in PDF format.
  420. ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes.
  421. Insulin Therapy and In-Hospital Mortality in Critically Ill Patients: Systematic Review and Meta-analysis of Randomized Controlled Trials.

    5 March 2006

  422. Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk. Free full text available in HTML and PDF formats.
  423. Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus.
  424. Association of schizophrenia and autoimmune diseases: linkage of Danish national registers.
  425. Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans.
  426. Early diabetic complications in a population of young patients with type 1 diabetes mellitus despite intensive treatment.
  427. Age at Onset of Childhood-Onset Type 1 Diabetes and the Development of End-Stage Renal Disease.
  428. Models for Predicting Type 1 Diabetes in Siblings of Affected Children.
  429. Patterns of Metabolic Progression to Type 1 Diabetes in the Diabetes Prevention Trial–Type 1.
  430. Role of Hepatic Glycogen Breakdown in Defective Counterregulation of Hypoglycemia in Intensively Treated Type 1 Diabetes.
  431. Increased Monocytic Activity and Biomarkers of Inflammation in Patients With Type 1 Diabetes.
  432. Gestational Diabetes Identifies Women at Risk for Permanent Type 1 and Type 2 Diabetes in Fertile Age: Predictive role of autoantibodies.
  433. Is neighbourhood deprivation a risk factor for gestational diabetes mellitus?
  434. Familial factors in diabetic nephropathy: an offspring study.
  435. Clinical studies is about pramlintide (Symlin).
  436. Inhibition of gastric emptying.
  437. Tissue expression and secretion of amylin.
  438. Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status.
  439. Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study. Free full text available in HTML and PDF formats.
  440. Endothelial Dysfunction and Low-Grade Inflammation Explain Much of the Excess Cardiovascular Mortality in Individuals With Type 2 Diabetes. The Hoorn Study.
  441. Depression Treatment and Satisfaction in a Multicultural Sample of Type 1 and Type 2 Diabetic Patients.
  442. Chromium Treatment Has No Effect in Patients With Poorly Controlled, Insulin-Treated Type 2 Diabetes in an Obese Western Population.

    26 February 2006

  443. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. See also U research holds hope for diabetics.
  444. The Bioartificial Pancreas: Progress and Challenges. Free full text available in PDF format.
  445. Strategies for Testing Long-Term Transcutaneous Amperometric Glucose Sensors. Free full text available in PDF format.
  446. Urinary oxidative stress markers in young patients with type 1 diabetes.
  447. Heart rate variability and circadian variations in type 1 diabetes mellitus.
  448. Stem Cell Breakthrough Helps 85% Of Type 2 Diabetes Patients.
  449. C-peptide exerts antithrombotic effects that are repressed by insulin in normal and diabetic mice.
  450. The joint diabetic-renal clinic in clinical practice: 10 years of data from a District General Hospital.
  451. Inverse relationship between allergic contact dermatitis and type 1 diabetes mellitus: a retrospective clinic-based study.
  452. Diabetes Mellitus and Risk of Colorectal Cancer in the Singapore Chinese Health Study. See also National University of Singapore Study Finds People With Diabetes May Have Higher Risk of Developing Colorectal Cancer.

    19 February 2006

  453. Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children.
  454. The role of diabetes duration, pubertal development and metabolic control in growth in children with type 1 diabetes mellitus.
  455. Pharmacokinetics and pharmacodynamics of intranasal insulin administered to patients with type 1 diabetes: a preliminary study.
  456. B-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification?
  457. Type 1 diabetes and latent autoimmune diabetes in adults (LADA): one end of the rainbow. Free full text available in PDF format.
  458. Gene therapy strategies towards immune tolerance to treat the autoimmune diseases.
  459. Acute effects of C-peptide on gastric emptying in longstanding type 1 diabetes.
  460. High prevalence of diabetic polyneuropathy in a group of Brazilian children with type 1 diabetes mellitus.
  461. Antiglycation properties of aged garlic extract: possible role in prevention of diabetic complications.
  462. Exploring the thrifty genotype's food-shortage assumptions: A cross-cultural comparison of ethnographic accounts of food security among foraging and agricultural societies.

    12 February 2006

  463. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function.
  464. Emerging Science Note/Sugar Blues.
  465. UVa Researchers Show that a Natural Carbohydrate can Help Lower Blood Sugar.
  466. Tsunami Induced Hyperglycemia and Diabetes Mortality - Two studies from South India. Also available in PDF format.

    5 February 2006

  467. Excess mortality in incident cases of diabetes mellitus aged 15 to 34 years at diagnosis: a population-based study (DISS) in Sweden.
  468. Taller Diabetics at Greater Risk for Amputation.
  469. Increased Myocardial Fatty Acid Metabolism in Patients With Type 1 Diabetes Mellitus. See also Diabetic heart is overdependent on fat.
  470. A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy.
  471. Expansion and redifferentiation of adult human pancreatic islet cells.

    29 January 2006

  472. Testing the Accelerator Hypothesis: Body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes.
  473. Quality of life after islet transplantation.
  474. Mean Blood Glucose and Biological Variation Have Greater Influence on HbA1c Levels Than Glucose Instability: An analysis of data from the Diabetes Control and Complications Trial.
  475. Neuropathy Among the Diabetes Control and Complications Trial Cohort 8 Years After Trial Completion.
  476. Cardiac Autonomic Neuropathy Predicts Cardiovascular Morbidity and Mortality in Type 1 Diabetic Patients With Diabetic Nephropathy.
  477. Serum Lipids and the Progression of Nephropathy in Type 1 Diabetes.
  478. Effects of Type 1 Diabetes on Gray Matter Density as Measured by Voxel-Based Morphometry.
  479. Microvascular Disease in Type 1 Diabetes Alters Brain Activation.
  480. Statins Prevent Dextrose-Induced Endothelial Barrier Dysfunction, Possibly Through Inhibition of Superoxide Formation.
  481. Diabetes prevalence in England, 2001-estimates from an epidemiological model.
  482. Coffee, Caffeine, and Risk of Type 2 Diabetes: A prospective cohort study in younger and middle-aged U.S. women.
  483. Monocyte Telomere Shortening and Oxidative DNA Damage in Type 2 Diabetes.

    22 January 2006

  484. Human fetal islet transplantation in type 1 diabetics: comparison of immunological effects between multiple implantation regimens.
  485. Cytoprotection of beta cells: rational gene transfer strategies.
  486. Allelic Variation in Key Peptide-Binding Pockets Discriminates between Closely Related Diabetes-Protective and Diabetes-Susceptible HLA-DQB1*06 Alleles.
  487. Preemptive transplantation for patients with diabetes-related kidney disease.
  488. Improved cardiovascular risk profile of patients with type 1 diabetes mellitus and renal failure after simultaneous pancreas-kidney transplantation.
  489. The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance. Free full text available in HTML and PDF formats. See also Diabetes from a Plastic? Estrogen mimic provokes insulin resistance.
  490. Gestational diabetes: The significance of persistent fasting hyperglycemia for the subsequent development of diabetes mellitus.
  491. Motor cortical excitability remains unaffected of short-term hyperglycemia in Type 1 diabetic patients.
  492. Painful diabetic neuropathy: a cross-sectional survey of health state impairment and treatment patterns.
  493. Treatment of intractable painful diabetic neuropathy with intravenous lignocaine.
  494. Urinary creatinine concentration is inversely related to glycaemic control and the presence of some diabetic complications in patients with newly diagnosed Type 2 diabetes.
  495. Things we have learned from tilapia islet xenotransplantation. (See Wikipedia for information about the tilapia.)

    15 January 2006

  496. Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children.
  497. Lower Consumption of Cow Milk Protein A1 beta-Casein at 2 Years of Age, Rather than Consumption among 11- to 14-Year-Old Adolescents, May Explain the Lower Incidence of Type 1 Diabetes in Iceland than in Scandinavia.
  498. Health Implications of Milk Containing beta-Casein with the A(2) Genetic Variant.
  499. Long-term (20 years) outcome and mortality of Type 1 diabetic patients in Soweto, South Africa.
  500. Excess mortality in Black compared with White patients with Type 1 diabetes: an examination of underlying causes.
  501. Total Homocysteine, Diet, and Lipid Profiles in Type 1 and Type 2 Diabetic and Nondiabetic Adolescents.
  502. Type 1 diabetes associated autoimmunity: Natural History, Genetic Associations and Screening. Free full text available in PDF format.
  503. The rise and fall of insulin secretion in type 1 diabetes mellitus.
  504. Is immunity in diabetic patients influencing the susceptibility to infections? Immunoglobulins, complement and phagocytic function in children and adolescents with type 1 diabetes mellitus.
  505. Immunomodulation in Type 1 Diabetes by NBI-6024, an Altered Peptide Ligand of the Insulin B Epitope.
  506. Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus.
  507. Insulin independence achieved with ultrasound-guided islet cell transplant.
  508. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Images, though not the full text, can be found at the Science Direct link. See also Brain important in lowering blood sugar.
  509. Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. See also Discovery of glucagon secretion mechanism may lead to improved therapies for diabetics.
  510. Time trends in the epidemiology of renal transplant patients with type 1 diabetes mellitus over the last four decades.

    8 January 2006

  511. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. Free full text available in PDF format.
  512. The bioartificial pancreas: progress and challenges.
  513. New diabetes form found by Norwegian researchers.
  514. Beyond the beta cell in diabetes. Also available in PDF format.
  515. Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset.
  516. Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children.
  517. Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus.

    1 January 2006

  518. Immunosuppression and Procedure-Related Complications in 26 Patients with Type 1 Diabetes Mellitus Receiving Allogeneic Islet Cell Transplantation.
  519. Time course of oxidative stress status in the postprandial and postabsorptive States in type 1 diabetes mellitus: relationship to glucose and lipid changes.
  520. In vivo imaging of islet transplantation.
  521. Interleukin-1 Stimulates beta-Cell Necrosis and Release of the Immunological Adjuvant HMGB1. Also available in PDF format.
  522. Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients.
  523. An association between type 1 diabetes and idiopathic generalized epilepsy.
  524. Immune responses to an encapsulated allogeneic islet beta-cell line in diabetic NOD mice.
  525. Bacterial and plant enterotoxin B subunit-autoantigen fusion proteins suppress diabetes insulitis.
  526. The Human Glomerular Podocyte Is a Novel Target for Insulin Action.

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