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Research News From 2018

    19 October 2018

  1. [New!] First Look at Control-IQ: A New-Generation Automated Insulin Delivery System.
  2. [New!] Effectiveness of artificial pancreas in the non-adult population: a systematic review and network meta-analysis.
  3. [New!] Maternal Antibiotic Use During Pregnancy and Type 1 Diabetes in Childrend-National Prospective Cohort Study.
  4. [New!] Recording of Diabetes on Death Certificates of Decedents With Type 1 Diabetes in DCCT/EDIC.
  5. [New!] Pharmacokinetics, Pharmacodynamics, and Modulation of Hepatic Glucose Production With Insulin Glargine U-300 and Glargine U-100 at Steady State With Individualized Clinical Doses in Type 1 Diabetes.

    10 October 2018

  6. Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial. Free full text available in PDF format. See also Algorithm Proves Better Than Humans at Controlling Blood Sugar in Type 1 Diabetes.
  7. Enlarging the loop: closed-loop insulin delivery for type 1 diabetes. Free full text available in PDF format.
  8. Women's Experiences of Day-and-Night Closed-Loop Insulin Delivery During Type 1 Diabetes Pregnancy.
  9. Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.

    3 October 2018

  10. Handling Exercise During Closed Loop Control. Free full text available in PDF format.
  11. Atherosclerosis and Microvascular Complications: Results From the Canadian Study of Longevity in Type 1 Diabetes.
  12. The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms.

    26 September 2018

  13. Association between maternal gluten intake and type 1 diabetes in offspring: national prospective cohort study in Denmark. Free full text available in PDF format. See also Gluten diet in pregnancy is linked to child diabetes.
  14. Psychosocial and Human Factors During a Trial of a Hybrid Closed Loop System for Type 1 Diabetes Management.
  15. Gastric emptying in children with type 1 diabetes mellitus: A pilot study.
  16. High Prevalence of Comorbid Autoimmune Diseases in Adults with Type 1 Diabetes from the HealthFacts Database.
  17. Do glucagon-like peptide-1 receptor (GLP-1R) agonists have potential as adjuncts in the treatment of type 1 diabetes?
  18. Will Genetic Engineering Carry Xenotransplantation of Pig Islets to the Clinic?

    19 September 2018

  19. Gut Microbiota Differs in Composition and Functionality Between Children With Type 1 Diabetes, MODY2, and Healthy Control Subjects: A Case-Control Study.
  20. Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring. Free full text available in PDF format.
  21. Insulin Combo Reduces After-Meal Sugar Spikes in Type 1 Diabetics.

    12 September 2018

  22. Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study. Free full text available in HTML reader format.
  23. Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes. See also Prolonged, high HbA1c may increase dementia risk in type 1 diabetes. (Free registration may be required.)
  24. Multivariable Artificial Pancreas for Various Exercise Types and Intensities.
  25. Risk factors for development and progression of diabetic retinopathy in Dutch patients with type 1 diabetes mellitus.
  26. The Coincidence of Newly Diagnosed Type 1 Diabetes Mellitus with IgM Antibody Positivity to Enteroviruses and Respiratory Tract Viruses. Free full text available in HTML and PDF formats.
  27. Comprehensive genetic screening: the prevalence of MODY gene variants in a population-based childhood diabetes cohort.
  28. Recruiting young pre-symptomatic children for a clinical trial in type 1 diabetes: Insights from the Fr1da insulin intervention study.
  29. Touch-actuated microneedle array patch for closed-loop transdermal drug delivery. Free full text available in HTML and PDF formats.

    5 September 2018

  30. Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes.
  31. Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes. Free full text available in HTML and PDF formats.
  32. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia.
  33. 29 August 2018

  34. Prospects for Primary Prevention of Type 1 Diabetes by Restoring a Disappearing Microbe.
  35. Cyclical variation in the incidence of childhood-onset type 1 diabetes during forty years in Navarra (Spain).
  36. Childhood onset type 1 diabetes at a tertiary hospital in south-western Iran during 2000-2015: Rapid increase in admissions and high prevalence of DKA at diagnosis.
  37. Islet Allotransplantation in the Bone Marrow of Patients With Type 1 Diabetes: A Pilot Randomized Trial.

    22 August 2018

  38. In-situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo. See also New type 1 diabetes therapy shows promise for long-term reversal in both humans, dogs.
  39. Clinical Evaluation of MK-2640: An Insulin Analog with Glucose-Responsive Properties.
  40. The bacteriome at the onset of type 1 diabetes: a study from four geographically distant African and Asian countries.
  41. Neurophysiological Evidence for a Compensatory Activity during a Simple Oddball Task in Adolescents with Type 1 Diabetes Mellitus. Free full text available in HTML and PDF formats.
  42. Microencapsulated adult porcine islets transplanted intraperitoneally in streptozotocin-diabetic non-human primates.
  43. Patient and family expectations of beta-cell replacement therapies in type 1 diabetes.

    15 August 2018

  44. Fasting hypoglycemia is associated with disease progression in presymptomatic early stage type 1 diabetes.
  45. Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes.
  46. Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil. Free full text available in PDF format.
  47. Studies Unable to Reproduce Results of Two Diabetes Papers.
  48. A Mathematical Model of Type 1 Diabetes Involving Leptin Effects on Glucose Metabolism.

    8 August 2018

  49. Performance of the Omnipod Personalized Model Predictive Control Algorithm with Meal Bolus Challenges in Adults with Type 1 Diabetes.
  50. Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.
  51. Efficacy and Safety of Dapagliflozin in Patients With Inadequately Controlled Type 1 Diabetes (the DEPICT-2 Study): 24-Week Results From a Randomized Controlled Trial.
  52. Persistent Elevations in Circulating INS DNA Among Subjects with Longstanding Type 1 Diabetes.
  53. Parental smoking and risk of childhood-onset type 1 diabetes.
  54. Multiresponsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery.

    1 August 2018

  55. Closed-Loop Driven by Control-to-Range Algorithm Outperforms Threshold-Low-Glucose-Suspend Insulin Delivery on Glucose Control Albeit not on Nocturnal Hypoglycemia in Pre-pubertal Patients with Type 1 Diabetes in Supervised Hotel Setting.
  56. Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.
  57. Baseline Glycated Hemoglobin Values Predict the Magnitude of Glycemic Improvement in Patients with Type 1 and Type 2 Diabetes: Subgroup Analyses from the DIAMOND Study Program.
  58. The Future of Islet Transplantation Is Now. Free full text available in HTML and PDF formats.

    25 July 2018

  59. Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity. Full text PDF available via link. See also Changes in bacterial mix linked to antibiotics increase risk for type 1 diabetes.
  60. Qualitative study of barriers to clinical trial retention in adults with recently diagnosed type 1 diabetes. Free full text available in HTML and PDF formats.
  61. Pet exposure in the family during pregnancy and risk for Type 1 diabetes - the prospective ABIS-study.
  62. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications.

    19 July 2018

  63. Artificial Pancreas: Clinical Study in Latin America Without Premeal Insulin Boluses.
  64. A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
  65. Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.

    4 July 2018

  66. Efficacy and safety of the artificial pancreas in the paediatric population with type 1 diabetes. Free full text available in HTML and PDF formats.
  67. Improving the Safety and Functionality of an Artificial Pancreas System for Use in Younger Children: Input from Parents and Physicians.
  68. Evaluation of an Artificial Pancreas with Enhanced Model Predictive Control and a Glucose Prediction Trust Index with Unannounced Exercise.
  69. Adaptability of Closed Loop During Labor, Delivery, and Postpartum: A Secondary Analysis of Data from Two Randomized Crossover Trials in Type 1 Diabetes Pregnancy. Free full text available in HTML and PDF formats.

    27 June 2018

  70. Safety and Performance of the Omnipod® Hybrid Closed-Loop System in Children Aged 6-12 Years with Type 1 Diabetes over Five Days Under Free-Living Conditions.
  71. Impact of macronutrient content of meals on postprandial glucose control in the context of closed-loop insulin delivery - a randomized cross-over study.
  72. Sotagliflozin in Combination With Optimized Insulin Therapy in Adults With Type 1 Diabetes: The North American inTandem1 Study.
  73. Ultra-rapid BioChaperone Lispro Improves post-prandial Blood Glucose Excursions versus Insulin Lispro in a 14-day crossover Treatment Study in Patients with Type 1 Diabetes.
  74. HbA1c and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study.
  75. Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations. Free full text available in PDF format. See also Joint Statement from JDRF and the American Diabetes Association.

    20 June 2018

  76. Challenges to Reshape the Future of Type 1 Diabetes Research.

    13 June 2018

  77. C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase. See also New hope from the 'seven year switch' in Type 1 diabetes.
  78. Antibiotics, acetaminophen and infections during prenatal and early life in relation to type 1 diabetes.
  79. New Horizons in the Treatment of Type 1 Diabetes: More Intense Immunosuppression and Beta Cell Replacement. Free full text available in HTML and PDF formats.

    6 June 2018

  80. Insulin-producing Cells from Adult Human Bone Marrow Mesenchymal Stromal Cells Could Control Chemically Induced Diabetes in Dogs: A Preliminary Study.
  81. Type 1 Diabetes Mellitus in Saudi Arabia: A Soaring Epidemic. Free full text available in HTML and PDF formats.
  82. Frequent Monitoring of C-peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home.
  83. Sex as a determinant of type 1 diabetes at diagnosis.

    23 May 2018

  84. Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis. Free full text available in HTML and PDF formats.
  85. Intake of polyunsaturated fatty acids and risk of preclinical and clinical type 1 diabetes in children-a systematic review and meta-analysis.
  86. Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): a multicentre, randomised controlled trial.
  87. Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets.

    16 May 2018

  88. Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study.
  89. Randomized Outpatient Trial of Single- and Dual-Hormone Closed-Loop Systems That Adapt to Exercise Using Wearable Sensors.
  90. Impact of genetic polymorphism in the β₂-receptor gene on risk of severe hypoglycemia in patients with type 1 diabetes.
  91. The impact of hypoglycaemia awareness status on regional brain responses to acute hypoglycaemia in men with type 1 diabetes.

    9 May 2018

  92. In-home nighttime predictive low glucose suspend experience in children and adults with type 1 diabetes.
  93. Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association? Free full text available in HTML and PDF formats.

    2 May 2018

  94. Factors associated with preservation of C-peptide levels at the diagnosis of type 1 diabetes.
  95. Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.

    25 April 2018

  96. Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices. Free full text available in HTML and PDF formats.
  97. Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis. Free full text available in HTML and PDF formats.
  98. Longitudinal assessment of hippocampus structure in children with Type 1 Diabetes.
  99. Impaired vibrotactile sense in children and adolescents with type 1 diabetes - Signs of peripheral neuropathy.
  100. Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy. Free full text available in HTML and PDF formats.

    18 April 2018

  101. Prospective study evaluating the use of nasal glucagon for the treatment of moderate to severe hypoglycaemia in adults with type 1 diabetes in a real‐world setting. Free full text available in PDF format. See also Nasal glucagon safe, effective in treating hypoglycemic events in children at home, school.
  102. Exploring Variation in Glycemic Control Across and Within Eight High-Income Countries: A Cross-Sectional Analysis of 64,666 Children and Adolescents With Type 1 Diabetes.
  103. Plasma Insulin Levels and Hypoglycemia Affect Subcutaneous Interstitial Glucose Concentration.
  104. Fully Closed-Loop Multiple Model Probabilistic Predictive Controller Artificial Pancreas Performance in Adolescents and Adults in a Supervised Hotel Setting.
  105. Persistence of abnormalities in white matter in children with type 1 diabetes.
  106. Study finds high rates of type 1 diabetes near food swamps.
  107. GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia.

    4 April 2018

  108. Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children. See also Genes can help predict children's risk of type 1 diabetes.
  109. The Economic Burden of Insulin-Related Hypoglycemia in Adults with Diabetes: An Analysis from the Perspective of the Italian Healthcare System.
  110. Trends in Diabetic Ketoacidosis Hospitalizations and In-Hospital Mortality - United States, 2000-2014. Free full text available in HTML and PDF formats.

    28 March 2018

  111. Economic Costs of Diabetes in the U.S. in 2017. Free full text available in PDF format.
  112. Automated Insulin Delivery Systems: Hopes and Expectations of Family Members.
  113. Hypoglycaemia Incidence and Recovery During Home Use of Hybrid Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes.
  114. Integration of Routine Parameters of Glycemic Variability in a Simple Screening Method for Partial Remission in Children with Type 1 Diabetes. Free full text available in HTML and PDF formats.
  115. Vitamin D Status, enterovirus infection, and type 1 diabetes in italian children/adolescents.
  116. Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful?
  117. Self-reported color-race and genomic ancestry in an admixed population: a contribution of a nationwide survey in patients with type 1 diabetes in Brazil.

    21 March 2018

  118. Unannounced Meals in the Artificial Pancreas: Detection Using Continuous Glucose Monitoring. Free full text available in HTML and PDF formats.
  119. Peptide Immunotherapy for Type 1 Diabetes-Clinical Advances. Free full text available in HTML and PDF formats.
  120. Superior Glycemic Control with a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts.
  121. Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions. See also Insulin Goes Viral?

    14 March 2018

  122. A phase 3 multicenter, open-label, prospective study designed to evaluate the effectiveness and ease of use of nasal glucagon in the treatment of moderate and severe hypoglycemia in children and adolescents with type 1 diabetes in the home or school setting.
  123. Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point. See also Researchers Confirm Entire Islet Organ is the Master Regulator of Blood Glucose Levels.
  124. α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
  125. Adrenaline and cortisol levels are lower during nighttime than daytime hypoglycaemia in children with type 1 diabetes.

    7 March 2018

  126. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. See also Diabetes is actually five separate diseases, research suggests.
  127. A prospective study evaluating the use of nasal glucagon for the treatment of moderate to severe hypoglycemia in adults with type 1 diabetes in a real-world setting.
  128. Seasonal Variation in Month of Diagnosis of Polish Children with Type 1 Diabetes - A Multicenter Study.
  129. Preventing Nocturnal Hypoglycemia: Single- vs Dual-Hormone Artificial Pancreas System.
  130. Safety and Efficacy of Epigenetically Converted Human Fibroblasts Into Insulin-Secreting Cells: A Preclinical Study.

    28 February 2018

  131. Clustering of microvascular complications in Type 1 diabetes mellitus.
  132. Human Subcutaneous Tissue Response to Glucose Sensors: Macrophages Accumulation Impact on Sensor Accuracy.

    21 February 2018

  133. A plateau in new onset type 1 diabetes: Incidence of pediatric diabetes in the United States Military Health System.
  134. Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. Free full text available in PDF format. See also Researchers find existing drug effective at preventing onset of type 1 diabetes.
  135. Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. See also Researchers discover link between gut and type 1 diabetes.
  136. Optimizing Hybrid Closed-Loop Therapy in Adolescents and Emerging Adults Using the MiniMed 670G System.

    14 February 2018

  137. Impact of erroneous meal insulin bolus with dual-hormone artificial pancreas using a simplified bolus strategy - A randomized controlled trial.
  138. Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycaemia in T1D.
  139. Beta Cell Function after Intensive Subcutaneous Insulin Therapy or Intravenous Insulin Infusion at Onset of T1D in Children without ketoacidosis.
  140. A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes.
  141. Administration of vitamin D and high dose of omega 3 to sustain remission of type 1 diabetes.
  142. Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes..
  143. Virus-like infection induces human β cell dedifferentiation.

    7 February 2018

  144. Overnight Glucose Control with Dual- and Single-Hormone Artificial Pancreas in Type 1 Diabetes with Hypoglycemia Unawareness: A Randomized Controlled Trial.
  145. Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia.
  146. A Prospective Multicenter Evaluation of the Accuracy of a Novel Implanted Continuous Glucose Sensor: PRECISE II.

    31 January 2018

  147. Excess Mortality in Patients With Type 1 Diabetes Without Albuminuria—Separating the Contribution of Early and Late Risks.
  148. Type 1 Diabetes in Parents and Risk of Attention Deficit Hyperactivity Disorder in Offspring: A Population-Based Study in Sweden.
  149. Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays.

    24 January 2018

  150. Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository. Free full text available in HTML and PDF formats.
  151. Dual-hormone artificial pancreas: benefits and limitations compared with single-hormone systems.
  152. Low-grade Inflammatory Marker Profile May Help to Differentiate Patients With LADA, Classic Adult-Onset Type 1 and Type 2 Diabetes.

    17 January 2018

  153. Early Infant Diet and Islet Autoimmunity in the TEDDY Study.
  154. Incidence of type 1 diabetes in China, 2010-13: population based study. See also Type 1 Diabetes on the Rise in China, Most New Cases in Adults.
  155. Incidence of childhood onset type 1 diabetes in Western Australia from 1985 to 2016: Evidence for a plateau.
  156. Basal Insulin Peglispro Increases Lipid Oxidation, Metabolic Flexibility, Thermogenesis And Ketone Bodies Compared To Insulin Glargine In Subjects With Type 1 Diabetes Mellitus.
  157. Efficacy and safety of fast-acting insulin aspart in comparison with insulin aspart in type 1 diabetes (onset 1): a 52-week, randomized, treat-to-target, phase 3 trial.

    10 January 2018

  158. Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial. See also Modifying baby formula doesn't prevent type 1 diabetes in children.
  159. Infant Feeding in Relation to the Risk of Advanced Islet Autoimmunity and Type 1 Diabetes in Children With Increased Genetic Susceptibility: A Cohort Study.
  160. Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.
  161. Reversible retinal vessel closure from VEGF-induced leukocyte plugging.
  162. Method may reverse vision loss from diabetes.
  163. Incidence of type 1 diabetes in China, 2010-13: population based study. Free full text available in HTML and PDF formats.

    3 January 2018

  164. Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study. Free full text available in HTML and PDF formats.
  165. Effect of a Glucagon Receptor Antibody (REMD-477) in Type 1 Diabetes: A Randomized Controlled Trial.
  166. Transplantation of Macro-encapsulated Human Islets within the Bioartificial Pancreas β Air to Patients with Type 1 Diabetes Mellitus.
  167. Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes. See also Spider web inspired implantable "string" could control diabetes.
  168. Incidence and prevalence trends of youth-onset type 2 diabetes in a cohort of Canadian youth: 2002-2013.

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Last Updated: Friday October 19, 2018 14:45:52
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