Mini-Dose Glucagon Rescue for Hypoglycemia in Children With Type 1 Diabetes
One of the greatest challenges that parents of children with diabetes face is caring for their children when they have a stomach illness. When kids have a stomach flu and aren't able to keep food down, blood sugars can drop quickly. With blood sugars dropping and kids unable to eat, parents often resort to a trip to the emergency room for an IV of glucose or a large dose of glucagon. A new study offers an easier alternative.
A Novel Idea
A team from the Texas Children's Hospital Diabetes Care Center came up with a novel idea: use very small doses of glucagon, injected subcutaneously using a regular insulin syringe, instead of the usual large dose of glucagon given IM as a way of staving off hypoglycemia in kids with a stomach illness (gastroenteritis) or who were not cooperating and needed food. Whereas a typical glucagon injection delivers 500 to 1,000 µg, the Texas Children's team suggested the following dosing schedule:
- 20 µg for kids ages 2 or under;
- 10 µg per year of age for kids from 2 to 15 (20 µg at age 2, 30 µg at age 3, etc.);
- 150 µg for kids 15 or older
How to Dose Glucagon
Parents were instructed to dilute the glucagon as instructed in the glucagon emergency kit, but then to use a standard U-100 insulin syringe (30, 50, or 100 units) to draw up the glucagon. Each "unit" on the U-100 insulin syringe corresponds to 10 µg of glucagon. Thus kids two or under received two "units" of glucagon, while a 10-year-old would receive 10 "units," based on the dosing schedule above. Parents monitored blood glucose every 30 minutes. If the child hadn't improved in 30 minutes, the dose was doubled and given again.
The results were excellent. Given in the doses outlined, blood sugars rose an average of 3.33-5.00 mmol/l (60-90 mg/dl) within 30 minutes and lasted for about an hour. Also, in the doses given as described, the glucagon did not cause an increase in nausea as is typical with large dose glucagon, and none of the kids vomited from the glucagon.
The team stressed that their approach is suitable for relative hypoglycemia in the face of stomach illness or lack of cooperation in eating, not unconsciousness due to severe hypoglycemia.