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Genetics and Heredity

I am 48 and have had Type 1 since I was 33. In March 1999 we determined the HLA antigens of my youngest son : DR2,7; DQ1,2; DR51,53. What is the possibility that my children will develop Type 1 diabetes?

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A surrogate mom candidate has a sibling with type 1 diabetes. What is the risk that the baby will have diabetes of any kind later in life? Is it reason enough to discount this candidate?

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What is the actual process of how diabetes affects the cell — the genetics behind the disease? I am African-American and I know that it affects our race tremendously.

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Can just one member of the family have something like a spontaneous mutation which would cause that person to have Type 1 diabetes?

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We have a family history of type 1 diabetes, thyroid problems, and medullary cancer. A friend who works in medical genetics says there is a syndrome in which some affected members get autoimmune diseases and some get endocrine cancers and suggests we get some genetic testing done for my three children. Is this a lot of endocrine stuff going on in one family, or is it just bad luck?

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My husband has type 1 diabetes we now have two beautiful daughters, and I recently “heard” a statistic that fathers are more likely to “pass” the likelihood of developing type 1 diabetes to their daughters in greater numbers than to any sons they may have. Are there any tests my daughters can have done that may indicate a predisposition to developing type 1 diabetes in the future?

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Both my four year son and I have diabetes, and my nine year old tested positive for celiac disease but her biopsy was negative. I know that in people with diabetes, 5-8% of people can develop celiac disease. What are the chances of developing diabetes if you tested positive for celiac disease?

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I was diagnosed with gestational diabetes at 26 weeks, and I’ve been on diet and insulin since then. My obstetrician has only been concerned with my glucose levels and wanted to induce at 38 weeks, but this morning he called and wants an amniocentesis due to high insulin requirements. Does this indicate a 36 week induction?

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My husband and his brother both have type 1 diabetes, and my 19 month old son was diagnosed last week. Are the chances still 6% that my three year old daughter will also be diagnosed? What can I watch for? Are there any tests to see if she will get diabetes?

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My youngest son has diabetes, but no other family member does. Why did it skip my other children?

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