Justin Delgado is husband to Kacie Doyle-Delgado, diagnosed at age 11. After more than a decade together, he considers himself to be an expert carb counter and Dexcom inserter. He graduated with his Master of Science in Finance from the University of Utah in 2013 and has been working in commercial banking since then. He attended his first Friends for Life conference in 2015 and is looking forward to volunteering with the teens.
March 8, 2000
Question from London, UK:
A friend has an 8 year old boy diagnosed with type 1 diabetes within the last year. They are having great trouble bringing down his blood sugar levels even with large amounts of insulin and he has been hospitalized on several occasions for treatment. From experience in hospital, it appears that he is resistant to insulin delivered by subcutaneous injection but that IV injections of insulin are effective. Why might he be resistant to subcutaneous injections of insulin? What approach could be taken to treating him at home?
The ‘subcutaneous-insulin resistance syndrome’ was first described in an article by Friedenberg, GR. and others in the New England Journal of Medicine, Volume 305, page 363,1981. Subsequent efforts to define this very rare syndrome more exactly were not successful and instead demonstrated that difficulties with compliance or other emotional problems in the family were responsible for the apparent resistance. Bearing these factors in mind, your friend’s son’s doctor might still want to explore the possibilities of inhaled insulin or oral polymer bound insulin, neither of which are I believe available yet in Britain or the US. The original solution was to co-inject a protease inhibitor called Trasylol.