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June 30, 2007

Insulin, Other

Question from India:

Can endothelial dysfunction cause decreased extravascular movement of insulin? In the case of delayed extravascular movement of insulin, will intact insulin persist in the blood for a period longer than its half life?


It is unlikely that endothelial dysfunction is caused by impaired movement of insulin. First, insulin is too small to be severely restricted across the endothelial barrier. This is not a limiting step. It is usually absolute insulin deficiency or insulin resistance of the tissues in the extracellular space that make the biggest difference.