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June 30, 2007

Insulin, Other

Question from India:

Can endothelial dysfunction cause decreased extravascular movement of insulin? In the case of delayed extravascular movement of insulin, will intact insulin persist in the blood for a period longer than its half life?

Answer:

It is unlikely that endothelial dysfunction is caused by impaired movement of insulin. First, insulin is too small to be severely restricted across the endothelial barrier. This is not a limiting step. It is usually absolute insulin deficiency or insulin resistance of the tissues in the extracellular space that make the biggest difference.

JTL