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March 31, 2008

Insulin

Question from India:

According to Wikipedia, "Increased potassium uptake - forces cells to absorb serum potassium; lack of insulin inhibits absorption. Arterial muscle tone - forces arterial wall muscle to relax, increasing blood flow, especially in micro arteries; lack of insulin reduces flow by allowing these muscles to contract." In view of these, can increased insulin cause decreased potassium, resulting in decreased neuromuscular activity and decreased filtration in the kidneys? Further, in view of increased insulin's involvement in dawn-regulation of insulin's receptors on target cells, can increased insulin address insulin resistance in some type 2 diabetic patients?

Answer:

No. However, when potassium is very high, one of the emergent treatments for hyperkalemia is insulin and glucose.

JTL