Justin Delgado is husband to Kacie Doyle-Delgado, diagnosed at age 11. After more than a decade together, he considers himself to be an expert carb counter and Dexcom inserter. He graduated with his Master of Science in Finance from the University of Utah in 2013 and has been working in commercial banking since then. He attended his first Friends for Life conference in 2015 and is looking forward to volunteering with the teens.
September 15, 2007
Question from India:
Can we consider insulin resistance as a tolerance or resistance to previous excessive or increased exposure of sugar or/and insulin in type 2 diabetics? Is such previous excessive or more exposure common up to some stages after getting type 2 diabetes? As such, can decreasing excessive intake of foods, exercising, withdrawal of oral diabetic medicines and injected insulin for some time can help in reversing insulin resistance? I mean reversing insulin resistance, but not just normalizing of glucose level temporarily.
Resistance can happen both ways. For instance, patients with type 1 diabetes are insulin resistant. They are exposed to high insulin levels with exogenous insulin therapy. This results in down-regulation of insulin receptors. We routinely clamp patients with good control with type 1 diabetes and they have insulin resistance, compared to age-matched healthy subjects. People with type 2 diabetes have insulin resistance as a result of a post-receptor defect in insulin signal transduction. It is clear that short-term food restriction or weight loss will decrease insulin resistance. However, there is no eliminating insulin resistance as a pathophysiologic process. The property is genetic and can be seen in first degree relatives of people with type 2 diabetes who are otherwise healthy. It can be decreased with healthy lifestyle.