Lg Cwd
Need Help

Submit your question to our team of health care professionals.

Current Question

See what's on the mind of the community right now.

Meet the Team

Learn more about our world-renowned team.

DTeam Archives

Review the entire archive according to the date it was posted.

October 9, 2001

Pills for Diabetes

Question from El Paso, Texas, USA:

Do thiazolidinediones cause a so-called fatty liver?


Rezulin [Rezulin, a pill for type 2 diabetes] was withdrawn from the market because of a rare, but potentially fatal, risk of drug-induced liver failure. The mechanism of the liver failure was not predictable. The other medications from the same group that are currently on the market, Actos [pioglitazone] and Avandia [rosiglitazone], do not have the same risk for the liver dysfunction.

In communicating this information, it is important to note that patients with poorly controlled type�2 diabetes develop fatty liver, and treatment with drugs like Rezulin have been shown to improve the fatty liver.