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May 27, 2001

Diagnosis and Symptoms

Question from New York, New York, USA:

There are new classifications of diabetes coming up all the time. How do MODY 1, 2 and 3 differ from each other?


From: DTeam Staff

There are now six or so Maturity Onset Diabetes of the Young variants. MODY 2 is due to a genetic deficiency in the glucokinase enzyme, another variant of which can cause diabetes in the newborn. MODY 1 and 3 are due respectively to genetic deficiencies in the proteins HNF (Hepatic Nuclear Factor) 4 and 1 respectively. Most cases of MODY, except for some in MODY 3, do not require insulin and are associated with a family history of being overweight.