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April 8, 2000

Nesidioblastosis

Question from Saltillo, Coahuila, M�xico:

I want to know if there is possible the diagnosis of nesidioblastosis in adult female with hypoglycemia. Growth hormone, cortisol and insulin blood levels are normal. The determination of C-peptide is in process.

Answer:

Nesidioblastosis is a disorder of infancy although it has been reported as an extreme rarity in adults. Hyperinsulinism at that age is usually due to a benign adenoma [insulin-secreting tumor of the pancreas; also called an insulinoma]. In any case both these conditions, assuming no laboratory error, are excluded by the normal serum insulin levels.

DOB