Justin Delgado is husband to Kacie Doyle-Delgado, diagnosed at age 11. After more than a decade together, he considers himself to be an expert carb counter and Dexcom inserter. He graduated with his Master of Science in Finance from the University of Utah in 2013 and has been working in commercial banking since then. He attended his first Friends for Life conference in 2015 and is looking forward to volunteering with the teens.
February 20, 2005
Question from Pennington Gap, Virginia, USA:
If a child has acanthosis nigricans, but has tested negative for diabetes, what are some other causes of this?
Acanthosis nigricans (AN) is often associated with insulin resistance and obesity. It is more common in people with darkly pigmented skin than in lighter skinned people. There is a benign, inherited type, usually in thinner people and this can occur in several family members. In association with obesity, polycystic ovaries, androgen excess conditions, hypertension and hyperlipidemia, it is often related to insulin resistance. Acanthosis nigricans can be confused with conditions where there is excess cortisone production (Cushing’s syndrome or Cushing’s disease) since both involve hyperpigmentation. Disorders such as lupus, scleroderma, Sjogren syndrome or Hashimoto’s thyroiditis rarely also are associated with AN. Medications such as high doses of niacin or nicotinic acid, high doses of corticosteroids and estrogens such as stilbestrol and oral contraceptives also rarely can e associated with AN. Pituitary and adrenal adenomas, as well as many kinds of cancers (i.e. adenocarcinomas), sometimes are associated with AN.