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February 16, 2002

Family Planning, Insulin Analogs

Question from Columbus, Ohio, USA:

Is Lantus safe to use in pregnancy? It seems the benefits of stable blood glucose levels may outweigh the risks associated with using it. Is it category C only because it is such a difficult thing to get something approved for pregnancy? Are there any real data to show there is a risk, or just lack of data?

Answer:

I am not aware of any new data on Lantus (insulin glargine) showing risk to a pregnancy. The risk in human pregnancies remains unknown.

Animal studies showed in some rat pups a mildly dilated cerebral ventricle. Whether this is significant or not is unclear. No other abnormalities were noted.

I have had a few patients on Lantus without problems, but you need thousands to make a definitive statement on safety.

OWJ