Lg Cwd
Need Help

Submit your question to our team of health care professionals.

Current Question

See what's on the mind of the community right now.

Meet the Team

Learn more about our world-renowned team.

DTeam Archives

Review the entire archive according to the date it was posted.

November 13, 2002

Insulin Analogs

Question from a physician in Bethesda, Maryland, USA:

My daughter has type�1 diabetes and is on Lantus and Humalog, which has had a positive impact in management of her diabetes. We store her unopened Lantus vials at 4 degrees Celsius, and once we have started a vial, we store it at room temp (20-25 degrees Celsius). Prior to the injection, we warm the vial (in a clean plastic baggy) under our arm for 5-10 minutes, which lessens the injection pain. However, I've noticed that after two-three weeks, the vials have visible floating particulates. It is not cloudy, but clearly the appearance has changed. I assume this is not a good thing, and I am concerned that it may make the Lantus potency less predictable. Have these particulates been described? Any suggestions for avoiding them?


It sounds like the insulin is either getting frozen or too warmed up. I would not use Lantus (insulin glargine) if it has particles floating around and would get a thermometer to check the temperature of your refrigerator.


[Editor’s comment: The Lantus label states “LANTUS must only be used if the solution is clear and colorless with no particles visible.”