Question from Sao Jose do Rio Preto, Sao Paulo, Brazil:
My 16 month old daughter, diagnosed at 10 months, takes 3.5 units of NPH (Novolin N) in the morning and 0.5 unit NPH before bedtime, and eventually 0, 5 Humalog when she's over 400 mg/dl [22.2 mmol/L]. The morning NPH seems to be acting a lot longer than it should, producing peaks (often with hypos) 14 to 16 hours latter, often between 12:00 pm and 2:00 am, and having her with readings around 100 mg/dl [5.5 mmol/L] even when she didn't have her 9 pm night shot (which seems to be bringing her to the 100s around noon the next day). However, her readings in the afternoon and before dinner are constantly above 400 mg/dl [22.2 mmol/L], but will go down to around 200 mg/dl [11.1 mmol/L] at 1:00 am, so we never use Humalog after 5 pm. Is NPH possibly having an extra-long action on her metabolism? Does it happen frequently with toddlers? Is there any other insulin we could expect to have intermediate action between Humalog/regular and NPH that she could use to cover between 12 and 7 pm and still be sure its action is over by bedtime?