Diabetes Research News
Current Research News - January 16, 2019
- Clinically significant cognitive impairment in older adults with type 1 diabetes.
- Predicting Progression to Type 1 Diabetes from Ages 3 to 6 in Islet Autoantibody Positive TEDDY Children.
- The Clinical Case for the Integration of a Ketone Sensor as Part of a Closed Loop Insulin Pump System.
- Glucose Control Using a Standard Versus an Enhanced Hybrid Closed Loop System: A Randomized Crossover Study.
- Metabolic effects of glucagon in humans. Free full text available in HTML and PDF formats.
Research News Archives
January 2, 2019
- Retinopathy and RAAS Activation: Results From the Canadian Study of Longevity in Type 1 Diabetes.
- Extracellular hemoglobin combined with an O2 -generating material overcomes O2 limitation in the bioartificial pancreas.
- Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. See also Mount Sinai Researchers Discover New Drug Cocktail That Increases Human Beta Cell Proliferation at Rapid Rates and Diabetes: New drug cocktail increases human beta cell proliferation at rapid rates.
- Immunomodulatory Effect of Vitamin D and Its Potential Role in the Prevention and Treatment of Type 1 Diabetes Mellitus-A Narrative Review. Free full text available in HTML and PDF formats.
December 26, 2018
- BioChaperone Lispro (BCLIS) vs faster aspart (FIA) and insulin aspart (ASP) in patients with type 1 diabetes on continuous subcutaneous insulin infusion: a randomized euglycemic clamp study.
- The Safety and Efficacy of Sodium Glucose Co-transporter 2 Inhibitors Combined with Insulin in Adults with Type 1 Diabetes: A Meta-analysis of Randomized Controlled Trials.
- Effectiveness of Preceding Solo Kidney Transplantation for Type 1 Diabetes With End-Stage Renal Failure.
- Earlier Puberty in Boys With Type 1 Diabetes Mellitus Compared to a Simultaneously Recruited Group of Control Adolescents.
- Determining the Effect of Diabetes Duration on Retinal And Choroidal Thicknesses in Children With Type 1 Diabetes Mellitus.
- Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis.
December 19, 2018
- Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset.
- Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.
- Low Level Insulin Content Within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes.
- Mortality in People With Type 1 Diabetes, Severe Hypoglycemia, and Impaired Awareness of Hypoglycemia Referred for Islet Transplantation. Free full text available in PDF format.
- Design and Clinical Evaluation of the Interoperable Artificial Pancreas System (iAPS) Smartphone App: Interoperable Components with Modular Design for Progressive Artificial Pancreas Research and Development.
- Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes.
- Scientists discovered mechanisms behind neonatal diabetes. See also Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
December 12, 2018
- Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.
- Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis.
- Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis.
- Location matters for insulin-producing cells.
December 5, 2018
- Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study.
- Type 1 Diabetes Incidence Set to Double in 20 Years in Europe. (Free Medscape membership required). See also 25-year study shows that incidence of type 1 diabetes is increasing by more than 3 percent per year in Europe.
- Global and regional estimates of the morbidity due to type I diabetes among children aged 0-4 years: a systematic review and analysis. Free full text available in HTML and PDF formats.
- DREAM5: An open-label, randomized, cross-over study to evaluate the safety and efficacy of day and night closed-loop control using the MD-Logic automated insulin delivery system compared to sensor augmented pump therapy in patients with type 1 diabetes at home.
November 28, 2018
- Learning From Past Failures of Oral Insulin Trials.
- Zinc transporter 8 autoantibodies (ZnT8-ab) are associated with higher prevalence of multiple diabetes-related autoantibodies in adults with type 1 diabetes.
- Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin requiring diabetes in China: a population based multicenter national wide survey.
- Localized immune tolerance from FasL-functionalized PLG scaffolds.
November 13, 2018
- Global and regional estimates of the morbidity due to type I diabetes among children aged 0-4 years: a systematic review and analysis. Free full text available in HTML and PDF formats.
- Maternal Dietary Supplement Use and Development of Islet Autoimmunity in the offspring: the TEDDY Study.
- Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study. Free full text available in HTML and PDF formats.
- Clinical Pharmacology of Fast-Acting Insulin Aspart Versus Insulin Aspart Measured as Free or Total Insulin Aspart and the Relation to Anti-Insulin Aspart Antibody Levels in Subjects with Type 1 Diabetes Mellitus.
- Resistance to Data Loss of Glycemic Variability Measurements in Long-Term Continuous Glucose Monitoring.
November 7, 2018
- First GWAS analysis of ‘type 1.5 diabetes’ reveals links between immune and metabolic disease.
- Long-Term Mortality After Kidney Transplantation in a Nationwide Cohort of Patients With Type 1 Diabetes in Finland.
- Single Centre Experience – Clinical Presentation and Frequency of Paediatric Diabetic Ketoacidosis (DKA) At Diagnosis over a 5-Year Period.
October 31, 2018
- The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes. Free full text available in HTML and PDF formats.
- The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Free full text available in HTML and PDF formats.
- Temporal development of the gut microbiome in early childhood from the TEDDY study. Free full text available in HTML and PDF formats. See also Different gut bugs in kids with type 1 diabetes.
- Low doses of dasiglucagon consistently increase plasma glucose levels from hypoglycaemia and euglycaemia in people with type 1 diabetes mellitus.
- Identification of nephropathy predictors in urine from children with a recent diagnosis of type 1 diabetes.
- Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease.
- Variables to Be Monitored via Biomedical Sensors for Complete Type 1 Diabetes Mellitus Management: An Extension of the “On-Board” Concept. Free full text available in HTML and PDF formats.
October 24, 2018
- Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.
- No Association Between Ljungan Virus Seropositivity and the Beta-Cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.
- Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease. Free full text available in HTML and PDF formats.
- Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice. Free full text available in HTML and PDF formats.
- Validation of Time in Range as an Outcome Measure for Diabetes Clinical Trials.
- First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes. See also New genetic study into LADA reveals connections to type 1 and type 2 diabetes.
