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Research News From February 2, 2011

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice. See also Rodent of the Week: A different approach to treating Type 1 diabetes and Destroying Glucagon Receptors May Cure Diabetes. Accelerated Insulin Pharmacokinetics and Improved Postprandial Glycemic Control in Patients With Type 1 Diabetes After Coadministration of Prandial Insulins With Hyaluronidase. (See also Halozyme Therapeutics Endocrinology Product Pipeline for more information.) The Possible Protective Role of Glucagon-Like Peptide 1 on Endothelium During the Meal and Evidence for an “Endothelial Resistance” to Glucagon-Like Peptide 1 in Diabetes . Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance […]

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Research News From January 26, 2011

Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Tests for Genetic Interactions in Type 1 Diabetes; Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs. Coexistent Autoimmunity in Familial Type 1 Diabetes: Increased Susceptibility in Sib-Pairs?

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Research News From January 19, 2011

Researchers find the enzyme at the heart of retinopathy caused by type 1 or type 2 diabetes. See also Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy. Closed-Loop Insulin Delivery During Pregnancy Complicated by Type 1 Diabetes. Proinsulin/C-peptide ratio, glucagon and remission in new-onset Type 1 diabetes mellitus in young adults. Effect of Automated Bio-Behavioral Feedback on the Control of Type 1 Diabetes. Anti-thymoglobulin (ATG) treatment does not reverse type 1 diabetes in the acute virally induced rat insulin promoter-lymphocytic choriomeningitis virus (RIP-LCMV) model.

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Research News From January 12, 2011

On the Occurrence of the Diabetes-Associated Antigen GAD 65 in Human Sera. A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy. Free full text available in HTML and PDF formats. Pregnancy-induced increase in circulating IGF-I is associated with progression of diabetic retinopathy in women with type 1 diabetes. Genetics of Type 1 Diabetes. Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes. Correction of Hyperglycemia in Type 1 Diabetic Models by Transplantation of Encapsulated Insulin-producing Cells Derived from Mouse Embryo Progenitor.

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Research News From January 5, 2011

HbA(1c) levels in schoolchildren with type 1 diabetes are seasonally variable and dependent on weather conditions. Low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes: a meta-analysis. Prospective comparison of two methods of screening for diabetic retinopathy by nonmydriatic fundus camera. Free full text available in HTML and PDF formats. Effects of Serving High-Sugar Cereals on Children’s Breakfast-Eating Behavior.

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Research News From December 29, 2010

Association of coxsackie virus infection and T lymphocyte subset changes with type 1 diabetes. Free full text available in PDF format. Intramuscular delivery of a naked DNA plasmid encoding proinsulin and pancreatic regenerating III protein ameliorates type 1 diabetes mellitus.

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Research News From December 22, 2010

Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies. Exenatide, a glucagon-like peptide-1 receptor agonist, suppresses pancreatic beta-cell destruction induced by encephalomyocarditis virus. Left ventricular diastolic dysfunction in adolescents with type 1 diabetes reflects the long- but not short-term metabolic control. A retrospective study of the incidence of diagnosed Type 1 diabetes among children and adolescents in a large health organization in Israel, 2000-2008. Rapid increase in the incidence of type 1 diabetes in Polish children from 1989 to 2004, and predictions for 2010 to 2025. Association between childhood obesity and subsequent Type 1 […]

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Research News From December 15, 2010

Analysis of pathogenesis of juvenile new onset diabetes. Cells reprogrammed to treat diabetes; Testes may be a source of insulin production. See also “Grow Your Own Transplant” May be Possible for Men with Type 1 Diabetes, Stem Cells Turned Into Complex, Functioning Intestinal Tissue in Lab, Stem Cells Used to Make Pancreas, Gut Cells and Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.

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Research News From December 8, 2010

Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial. Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results. Efficacy Determinants of Subcutaneous Microdose Glucagon during Closed-Loop Control. Factors influencing the effectiveness of glucagon for preventing hypoglycemia.

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Research News From December 1, 2010

Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes The Allegheny County Type 1 Diabetes Registry. See also Type 1 Diabetes Death Rate is Falling, But Not Fast Enough. Preclinical arterial disease in patients with type 1 diabetes without other major cardiovascular risk factors or macro-microvascular disease. Danish children born 1981-2002 with GAD65 and IA-2 autoantibodies at birth had an increased risk to develop type 1 diabetes before 2004. Cognitive functioning in type 1 diabetes: the Diabetes Control and Complications Trial (DCCT) revisited. Detection of nocturnal hypoglycemic episodes using EEG signals.

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