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Research News From February 24, 2008

Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Cytomegalovirus infection in early infancy: risk of induction and progression of autoimmunity associated with type 1 diabetes. Winner of the 2007 Society for Thermal Medicine Young Investigator Award Fever-range whole body hyperthermia prevents the onset of type 1 diabetes in non-obese diabetic mice. Generation of Insulin-producing Beta Cells from Stem Cells – Perspectives for Cell Therapy in Type 1 Diabetes.

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Research News From February 17, 2008

Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype. Environmental risk factors in prediction of childhood prediabetes. Free full text available in PDF format. The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus. Glycemic Variability: Should we and can we prevent it? Phenotype changes at the onset of type 1 diabetes in young adults from a Mediterranean area throughout the last decade. High-Normal Serum Uric Acid Is Associated with Impaired Glomerular Filtration Rate in Nonproteinuric Patients with Type 1 Diabetes. Glycosaminoglycans urinary excretion as […]

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Research News From February 10, 2008

Fully Automated Closed-Loop Insulin Delivery vs. Semi-Automated Hybrid Control in Pediatric Patients with Type 1 Diabetes using an Artificial Pancreas. A unifying hypothesis on the development of type 1 diabetes and celiac disease: Gluten consumption may be a shared causative factor. Association of Urinary Inflammatory Markers and Renal Decline in Microalbuminuric Type 1 Diabetics. The effect of oral folic acid upon plasma homocysteine, endothelial function and oxidative stress in patients with type 1 diabetes and microalbuminuria. Diagnostic potential of oxidative stress markers in children and adolescents with type 1 diabetes. HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: […]

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Research News From February 3, 2008

Is C-peptide replacement the missing link for successful treatment of neurological complications in type 1 diabetes? Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes? Time series analysis of ultraviolet B radiation and type 1 diabetes in Newfoundland. Very high and increasing incidence of type 1 diabetes mellitus in Newfoundland and Labrador, Canada. Maternal diet during pregnancy and islet autoimmunity in offspring. The Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial — Revisited. Genetically engineered K cells provide sufficient insulin to correct […]

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Research News From January 27, 2008

Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes. Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus Using Serum and Functional Genomics. The effects of metabolic control on oxidized low-density lipoprotein antibodies in children and adolescents with type 1 diabetes mellitus. Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus. Plasma {alpha}-defensin is associated with cardiovascular morbidity and mortality in type 1 diabetic patients. Free full text available in PDF format. Interleukin-12 and tumour necrosis factor-alpha equilibrium is a prerequisite for clinical course free […]

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Research News From January 13, 2008

Vaccination against self to prevent autoimmune disease: the type 1 diabetes model. Mutations in the Insulin Gene can Cause MODY and Autoantibody-Negative Type 1 Diabetes. The Relationship Between Diabetes Mellitus and Traffic-Related Air Pollution. AIR� Inhaled Insulin versus Subcutaneous Insulin: Pharmacokinetics, Glucodynamics, and Pulmonary Function in Asthma. Relationship between plasma sialic acid and fibrinogen concentration and incident micro- and macrovascular complications in type 1 diabetes. The EURODIAB Prospective Complications Study (PCS). Hypothesis-Ultraviolet-B Irradiance and Vitamin D Reduce the Risk of Viral Infections and thus Their Sequelae, Including Autoimmune Diseases and some Cancers.

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Research News From January 6, 2008

Extent of Beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus. Free full text available in HTML and PDF formats (see link in full text HTML). Heterozygous Missense Mutations in the Insulin Gene are linked to Permanent Diabetes appearing in the Neonatal Period or in Early-Infancy: A report from the French ND Study Group. Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort. Nanoparticle strategies for the oral delivery of insulin.

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Research News From December 30, 2007

No change in apolipoprotein AI metabolism when subcutaneous insulin infusion is replaced by intraperitoneal insulin infusion in type 1 diabetic patients. Insulin Mutation Screening in 1044 Patients with Diabetes: Mutations in the INS gene are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood. Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia. Plasma concentration of asymmetric dimethylarginine (ADMA) predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy. Effects of pyridoxamine in combined phase 2 studies of patients with […]

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Research News From December 23, 2007

Effects of controlled hypoglycaemia on cardiac repolarisation in patients with type 1 diabetes. “Type 1 on type 2” diabetes mellitus: autoimmune type 1 diabetes superimposed on established type 2 diabetes. Free full text available in PDF format. Proinsulin C-peptide abrogates type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats. Prevalence and determinants of elevated apolipoprotein B and dense LDL in youths with type 1 and type 2 diabetes. Free full text available in PDF format. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. A genome-wide scan for […]

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Research News From December 16, 2007

The Long Road to Beta Cells — Quest for type 1 diabetes cure inches forward. Knock Out, Knock In, Knock Down � Genetically Manipulated Mice and the Nobel Prize (PDF version) summarizes the process of removing and inserting genes into an animal’s DNA, which is used extensively in research, including diabetes-related research. Humoral immune responses of Type-1 Diabetes patients to M. avium subspecies paratuberculosis lend support to the infectious trigger hypothesis. Regulated beta-cell regeneration in the adult mouse pancreas. Treatment of type 1 diabetes by transplantation of bone-derived mesenchymal stem cells expressing human insulin gene: experiment with mice. Defining pancreatic […]

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