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Proinsulin C-peptide — the bioactive peptide with a huge promise. A Risk Score for Type 1 Diabetes Derived from Autoantibody Positive Participants in The Diabetes Prevention Trial- Type 1. Familiality of diabetes mellitus. The occurrence and analysis of chosen risk factors of DKA among children with new onset of DMT1. Double or hybrid diabetes associated with an increase in type 1 and type 2 diabetes in children and youths. Epidemiology of childhood type 2 diabetes and obesity. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. Free full text available in HTML and PDF formats. B cell depletion: […]

Increasing GLP-1-induced �-cell Proliferation By Silencing The Negative Regulators Of Signaling CREM And DUSP14. Murine Anti-Thymocyte Globulin Therapy Alters Disease Progression in NOD Mice by a Time Dependent Induction of Immunoregulation. Novel human protein networks of genetic interactions in type 1 diabetes. The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes. Free full text available in PDF format. Parental country of birth is a major determinant of childhood type 1 diabetes in Sweden. Seasonality of month of birth differs between type 1 diabetes patients with pronounced beta-cell autoimmunity and individuals […]

Family history of diabetes, autoimmunity, and risk factors for cardiovascular disease among children with diabetes in the SEARCH for Diabetes in Youth Study. The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus. Increased TLR2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Pro-inflammatory state. Free full text available in PDF format. Essential roles of TGF-{beta} in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells. Free full text available in PDF format.

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Sex-specific association of the human PTPN22 1858T-allele with type 1 diabetes. A Risk Score for Type 1 Diabetes Derived from Autoantibody Positive Participants in The Diabetes Prevention Trial- Type 1. Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: Insights from echocardiography and exercise cardiac performance evaluation. Progression of coronary artery calcium in type 1 diabetes mellitus. An Insulin Infusion […]

Glucagon-like-peptide-1 inhibits blood-brain glucose transfer in humans. Prevalence of vitamin D receptor gene polymorphism in a Uruguayan population and its relation to type 1 diabetes mellitus. Pro-inflammatory Variants of DRB1 and RAGE Genes Are Associated with Susceptibility to Pediatric Type 1 Diabetes: A New Hypothesis on the Adaptive Role of Autoimmunity. Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations. Comparative therapeutic effects of orally administered 1,25-dihydroxyvitamin D(3) and 1alpha-hydroxyvitamin D(3) on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet. Pancreatic Islet Cell Transplant for Treatment of […]

Early infant feeding and risk of type 1 diabetes mellitus-a nationwide population-based case-control study in pre-school children. Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of pancreatic B-cells 12 months after diagnosis. Occurrence of enterovirus RNA in serum of children with newly diagnosed type 1 diabetes and islet cell autoantibody-positive subjects in a population with a low incidence of type 1 diabetes. Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study. Free full text available in PDF format. Stem cell genes may provide […]

Immune intervention at diagnosis–should we treat children to preserve beta-cell function? Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice. Putative Delays in Interstitial Fluid (ISF) Glucose Kinetics Can Be Attributed to the Glucose Sensing Systems Used to Measure Them Rather Than the Delay in ISF Glucose Itself. Worldwide childhood type 1 diabetes incidence–what can we learn from epidemiology? Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered? Identifying children at particular risk of long-term diabetes complications. Sequence of progression of albuminuria and decreased GFR in persons with type 1 diabetes: […]

Type 1 diabetes intervention trials 2007: where are we and where are we going? Pancreas and islet cell transplantation in diabetes. Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques. See also Cross-species transplant in rhesus macaques is step toward diabetes cure for humans. Induction of insulin secretion in engineered liver cells by nitric oxide. Free full text available in PDF format. Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method. The effect of birth order and parental age on the risk of type 1 and 2 diabetes among young adults. Abnormal […]

Differential anti-diabetic efficacy of incretin agonists vs. DPP-4 inhibition in high fat fed mice. Beta-cell replacement in immunosuppressed recipients: old and new clinical indications. Functional waning of naturally-occurring CD4+ regulatory T cells contributes to the onset of autoimmune diabetes. Pluripotency Redux � Advances in Stem-Cell Research. See also Interview with Douglas Melton on the promise and limitations of recent advances in stem-cell research. Highly poly(ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication. Inhaled insulin using AERx insulin Diabetes Management System (AERx iDMS). Hyperplastic islets observed in “reversed” NOD mice treated without hematopoietic cells. Mesenchymal Stem Cells Cooperate […]

Inhibition of PKCepsilon Improves Glucose-Stimulated Insulin Secretion and Reduces Insulin Clearance. See also Proinsulin maturation, misfolding, and proteotoxicity and Sabotage in the insulin factory? Botched production of insulin molecule may kill pancreas cells and lead to diabetes, U-M study finds. Solving a critical part of the insulin puzzle. See also Aussie scientists make diabetes breakthrough. SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B. Free full text available in HTML and PDF formats. Fatty Acids And Insulin Modulate Myocardial Substrate Metabolism In Humans With Type 1 Diabetes Mellitus. Multiple SOD1/SFRS15 variants are associated with the development and progression of […]