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Research News From September 30, 2007
Omega-3 Polyunsaturated Fatty Acid Intake and Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes. See also Omega-3s may protect children from diabetes and Omega-3s fight diabetes. Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989. Free full text available in HTML and PDF formats. Glycaemic control and antibody status among patients with newly diagnosed Type 1 diabetes. Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study. Environmental causes of type […]
Read MoreResearch News From September 23, 2007
Prediction of the clinical remission using the C-peptide level in type 1 diabetes in children. Familial Risk Factors for Microvascular Complications And Differential Male-Female Risk in a Large Cohort of American Families with Type 1 Diabetes. Free full text available in PDF format. Defective function of the Fas apoptotic pathway in type 1 diabetes mellitus correlates with age at onset. Quality of life after islet transplant: impact of the number of islet infusions and metabolic outcome. Development and preclinical assessment of a bioartificial pancreas. Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse. Arterial hypertension […]
Read MoreResearch News From September 16, 2007
Beta Cell transplantation and immunosuppression: can’t live with it, can’t live without it. Early Nutrition and Risk of Type 1 Diabetes Mellitus – A Nationwide Case-control Study in Preschool Children. The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Impairment of skin capillary recruitment precedes chronic complications in patients with type 1 diabetes. Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children. Human islets derived from donors after cardiac death are fully biofunctional. Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways. Beta-cell replacement and regeneration: Strategies […]
Read MoreResearch News From September 9, 2007
Recovery from diabetes in mice by � cell regeneration. Free full text available in HTML and PDF formats. Prediction of type 1 diabetes among siblings of affected children and in the general population. Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis. Circulating CD4+CD25 high regulatory T cells and natural killer T cells in children with newly diagnosed type 1 diabetes or with diabetes-associated autoantibodies. CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes. Evidence of Increased Inflammation […]
Read MoreResearch News From September 2, 2007
HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population. Expression of cholera toxin B�proinsulin fusion protein in lettuce and tobacco chloroplasts � oral administration protects against development of insulitis in non-obese diabetic mice. See also Insulin Grown in Plants Relieves Diabetes in Mice; UCF Study Holds Promise for Humans and Local Professor Begins Human Trials For Diabetes Cure. Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes. Vessel wall stiffness in Type 1 diabetes, and the central hemodynamic effects of acute hypoglycemia. Plasma endothelin response to acute hypoglycaemia in adults […]
Read MoreResearch News From August 19, 2007
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Length of gestation and gender are associated with HLA genotypes at risk for Type 1 diabetes (Italian DIABFIN 3). Epidemiology and genetic risk of type 1 diabetes among children in Aragon community, Spain. Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitus.
Read MoreResearch News From August 12, 2007
Evidence of Increased Inflammation and Monocytic Activity in Patients with Type 1 Diabetes: plausible role in Microvascular Complications. Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice. Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives. Evidence for a Role of Superoxide Generation in Glucose Induced �-cell Dysfunction In Vivo. Non-invasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes. Polymorphism of bovine beta-casein and its potential effect on human health is the full text in PDF of an article referenced last week and explores the hypothesis that […]
Read MoreResearch News From August 5, 2007
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 mAb by enhancing recovery of {beta} cells. Impact of Oxidative Stress on the Endothelial Dysfunction of Children and Adolescents With Type 1 Diabetes Mellitus: Protection by Superoxide Dismutase? Rotavirus infections and development of type 1 diabetes: an evasive conundrum. IGF-1 and leptin associate with fetal HDL-cholesterol at birth: examination in offspring of mothers with type 1 diabetes. Influence of glycemic variables on hemoglobin A1c. Polymorphism of bovine beta-casein and its potential effect on human health. Immunoregulatory […]
Read MoreResearch News From July 29, 2007
Oxidative stress in childhood type 1 diabetes: Results from a study covering the first 20 years of evolution. Prevalence and prognostic implications of the metabolic syndrome in community-based patients with type 1 diabetes: The Fremantle Diabetes Study. Presence of GAD Antibodies During Gestational Diabetes Mellitus Predicts Type 1 Diabetes. The Effect of Medical Therapy and Islet Cell Transplantation on Diabetic Nephropathy: An Interim Report. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey.
Read MoreResearch News From July 22, 2007
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. See also Uncovered: New Gene Linked To Type 1 Diabetes In Children, USA and Gene Discovered For Type 1 Diabetes In Children. Carotid intima-media thickness in pediatric type 1 diabetes patients. Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes. Renal hemodynamic changes and renal functional reserve in children with type I diabetes mellitus. The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey. Advanced Glycation End Products (AGEs) and Cardiovascular Disease (CVD) […]
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