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Research News From July 15, 2007

Diabetic nephropathy in 27,805 children, adolescents and adults with type 1 diabetes: effect of diabetes duration, HbA1c, hypertension, dyslipidemia, diabetes onset and gender. Early changes in glomerular size selectivity in young adults with type 1 diabetes and retinopathy. Results from the Diabetes Incidence Study in Sweden. Association of VEGF-1499C–>T polymorphism with diabetic nephropathy in type 1 diabetes mellitus. Higher Prevalence of Elevated Albumin Excretion in Youth with Type 2 than Type 1 Diabetes: The SEARCH for Diabetes in Youth Study. The effect of exercise on the absorption of inhaled human insulin via the AERx� iDMS in people with type 1 […]

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Research News From July 8, 2007

Generation of Insulin-producing Cells From Human Bone Marrow Mesenchymal Stem Cells By Genetic Manipulation. Maternal Psychological Reaction to Newborn Genetic Screening for Type 1 Diabetes. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. See also CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Australian children and adolescents with type 1 diabetes have low vitamin D levels. Also available in PDF format (see page 3). T cell immunomodulation-the Holy Grail of therapeutic tolerance. Prevalence of autoimmune diseases in islet transplant candidates with severe hypoglycaemia and glycaemic […]

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Research News From July 1, 2007

Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy. Telmisartan Shows an Equivalent Effect of Vitamin C in Further Improving Endothelial Dysfunction After Glycemia Normalization in Type 1 Diabetes. Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin study. The effect of ramipril therapy on cytokines and parameters of incipient diabetic nephropathy in patients with type 1 diabetes mellitus. Prospective Study of Type 1 and Type 2 Diabetes and Risk of Stroke Subtypes; The Nurses’ Health Study. Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury.

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Research News From June 24, 2007

Exenatide blocks JAK1-STAT1 in pancreatic beta cells. Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus. Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis. Free full text available in PDF format. Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development. Organ specific autoantibodies in preclinical and early clinical type 1 diabetes in Turkey. Influence of stressful life events on the onset of Type 1 diabetes in childhood.

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Research News From June 17, 2007

Pancreatic islet transplantation, what has been achieved since Edmonton break-through. Participant and Parent Experiences in the Parenteral Insulin Arm of the Diabetes Prevention Trial for Type 1 Diabetes. Islet autoantibody development during follow-up of high-risk children from the general Norwegian population from three months of age: Design and early results from the MIDIA study. Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Interferons induce an antiviral state in human pancreatic islet cells. Differentiation of transplanted microencapsulated fetal pancreatic cells. Diabetes Patient Successfully Transplanted in World-first DiabeCell� Trial. See also LCT awarded world-first […]

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Research News From June 10, 2007

Stressful life events and psychological dysfunctions before the onset of type 1 diabetes mellitus. Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume. Decreased blood dendritic cell counts in type 1 diabetic children. Simple switch turns cells embryonic; Technique removes need for eggs or embryos. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Free full text available in HTML and PDF formats.

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Research News From June 3, 2007

Major increase in Type 1 diabetes-no support for the Accelerator Hypothesis. Engineered enteroendocrine cells secrete insulin in response to glucose and reverse hyperglycemia in diabetic mice. Association between Glycosylated Hemoglobin Level and Cardiovascular and All-Cause Mortality in Type 1 Diabetes. Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetes. A method to predict the metabolic effects of changes in insulin treatment in subgroups of a large population based patient cohort. The Role of Insulin […]

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Research News From May 27, 2007

Normalization of the IGF-IGFBP Axis by Sustained Nightly Insulinization in Type 1 Diabetes. Orange Juice or Fructose Intake Does Not Induce Oxidative and Inflammatory Response. Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes. Effect of BMI on Lifetime Risk for Diabetes in the U.S. Childhood Obesity and Metabolic Imprinting: The Ongoing Effects of Maternal Hyperglycemia. Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin. Genetic and phenotypic diversity of echovirus 30 strains and pathogenesis of type 1 diabetes. Discordant expression of pro-B-type and pro-C-type […]

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Research News From May 20, 2007

Control of T cell mediated autoimmunity by metabolite flux to N-glycan biosynthesis. Free full text available in PDF format. See also Glucosamine-like supplement inhibits multiple sclerosis, type 1 diabetes. The Role of HLA Class I Gene Variation in Autoimmune Diabetes. Free full text available in HTML and PDF formats. Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie B virus infection. Transfusion of Apoptotic � Cells Induces Immune Tolerance to � Cell Antigens and Prevents Type 1 Diabetes in NOD Mice. Multiple variants in Vascular Endothelial Growth Factor (VEGF) are risk factors for time […]

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Research News From May 13, 2007

A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes among young adults in Finland between 1992 and 1996. Three-yr follow-up of a type 1 diabetes mellitus patient with an islet xenotransplant. Long-term treatment with the apolipoprotein mimetic peptide D-4F increases antioxidants and vascular repair in Type I diabetic rats. Free full text available in PDF format.

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