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The Burden of Diabetes Mellitus Among US Youth: Prevalence Estimates From the SEARCH for Diabetes in Youth Study. See also Study Finds One in 523 Children and Adolescents Have Diabetes. ABC News has two online videos about the recent study published in The New England Journal of Medicine (International Trial of the Edmonton Protocol for Islet Transplantation): Summary of the Study and Interview with Dr. Camillo Ricordi from the DRI. Therapy with the hsp60 peptide DiaPep277(TM) in C-peptide positive type 1 diabetes patients. See also The Swedish GAD-vaccination Trial: Outcomes of a Phase II Safety and Efficacy Trial with Diamyd(TM) […]

International Trial of the Edmonton Protocol for Islet Transplantation reviews the history of islet cell transplantation and concludes that “… insulin independence is usually not sustainable.” See also Diabetes Treatment Disappoints in New Study. Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects. Cholesterol Absorption and Synthesis in Children With Type 1 Diabetes. Paradoxically enhanced heart tolerance to ischaemia in type 1 diabetes and role of increased osmolarity. Oxidative stress markers in plasma and urine of prepubertal patients with type 1 diabetes mellitus. Modeling Chronic Glycemic Exposure Variables as Correlates and Predictors of Microvascular Complications of Diabetes. […]

The Politics and Promise of Stem-Cell Research is an editorial published in the September 21, 2006 issue of The New England Journal of Medicine. Also available in PDF format. See also Bit Player or Powerhouse? China and Stem-Cell Research, also available in PDF format; Stem cells–a clinical update which has free full text available in PDF format; and Naturally dead embryos yield stem cells. Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells. Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice. A multicenter, double-blind, safety study of QR-333 for […]

Switching from Insulin to Oral Sulfonylureas in Patients with Diabetes Due to Kir6.2 Mutations. See also Activating Mutations in the ABCC8 Gene in Neonatal Diabetes Mellitus, Drug Restores Insulin Secretion for Rare Type 1 Cases, and Molecular medicine comes to the rescue: Targeted therapy turns life around for child with neonatal diabetes. Parents of children who were diagnosed before 6 months of age should speak with their diabetes team about this research. Effect of Ramipril on the Incidence of Diabetes. The DREAM Trial Investigators. Full text available in PDF format. See also Angiotensin-Converting�Enzyme Inhibitors for Impaired Glucose Tolerance � Is […]

Researchers Uncover Gene That Raises Risk for Type 1 Diabetes. Extrapancreatic Proinsulin/Insulin-expressing Cells in Diabetes Mellitus: Is History Repeating Itself? Effects of a vitamin D(3) analog on diabetes in the bio breeding (BB) rat. Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes. Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes. Treatment burden and health-related quality of life of children with diabetes, cystic fibrosis and asthma. Glucose abnormalities in a 14-year old patient treated with a second generation antipsychotic. A case study.

A screening system for detecting genetic risk markers of type 1 diabetes in dried blood spots. Secondary prevention of type 1 diabetes mellitus: stopping immune destruction and promoting beta-cell regeneration. Full text available in HTML and PDF formats. Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes. Development of microvascular complications in type 1 diabetic patients 10 years follow-up. Risk factors of diabetic nephropathy progression in patients with a long history of diabetic mellitus as shown by a retrospective analysis. Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the […]

Drug Insight: new immunomodulatory therapies in type 1 diabetes. C-Peptide Does Not Affect Ocular Blood Flow in Patients With Type 1 Diabetes. Natural History and Risk Factors for Microalbuminuria in Adolescents With Type 1 Diabetes. Oesophageal motility disorders in type 1 diabetes mellitus and their relation to cardiovascular autonomic neuropathy. Decline in Neurophysiological Function After 7 Years in an Adolescent Diabetic Cohort and the Role of Aldose Reductase Gene Polymorphisms. The visceral and subcutaneous fat changes in type 1 diabetes: a pilot study. Apolipoprotein B as a long-term predictor of mortality in type 1 diabetes mellitus: a 15-year follow up. […]

Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999. Diabetes preventive gluten-free diet decreases the number of caecal bacteria in non-obese diabetic mice. Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association Studies. Early Manifestation of Type 1 Diabetes in Children Is a Risk Factor for Changed Bone Geometry: Data Using Peripheral Quantitative Computed Tomography. Effects of aspirin plus alpha-tocopherol on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus. Possible effect of leptin on renal magnesium excretion in adolescent patients with type 1 diabetes. The effects of calcitriol […]

Vascular endothelial and smooth muscle function relate to body mass index and glucose in obese and non-obese children. Full text available in PDF format. Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes. Full text available in PDF format. Evaluation of the left ventricular hemodynamic function and myocardial perfusion by gated single photon emission tomography, in patients with type 1 diabetes mellitus; prodromal signs of cardiovascular disease after four years. Polymorphism I/D of the angiotensin-converting enzyme gene and disturbance of blood prssure in type 1 diabetic children and adolescents. Effect of standard nicotinamide in the prevention of […]

Rotavirus-specific T cell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes. Costimulation couture: a designer approach to regulating autoimmunity. Full text available in HTML and PDF formats. Current status of pancreatic islet transplantation. Prevalence of EGG Derangement in Newly Diagnosed Type 1 Diabetes in Childhood. Iron-binding antioxidant capacity is impaired in diabetes mellitus. Cellular basis of diabetic nephropathy: IV Antioxidant enzyme mRNA expression levels in skin fibroblasts of type 1 diabetic sibling pairs. TIME magazine reports on Stem Cells: The Hope And The Hype.