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Dr. Denise Faustman offers a Fall 2005 Update on her work to cure type 1 diabetes. Islet neogenesis: A potential therapeutic tool in type 1 diabetes. Immunological mechanisms associated with long-term remission of human type 1 diabetes. How robust is the evidence for viruses in the induction of type 1 diabetes? Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes. Soluble, dimeric HLA DR4-peptide chimeras: An approach for detection and immunoregulation of human type-1 diabetes. The impact of diabetes on cognition: What can be learned from rodent models? Incidence of end-stage renal disease in patients […]

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? The thymus way in pathogenesis and prevention of type 1 diabetes. A two year observational study of nicotinamide and intensive insulin therapy in patients with recent onset type 1 diabetes mellitus. Altered glycemia and brain-update and potential relevance to the aging brain. Absence of breast-feeding is associated with the risk of type 1 diabetes: a case-control study in a population with rapidly increasing incidence. Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus: Role of insulin and C-peptide. Hypoxic stress in diabetic […]

Mothers’ Experiences of Serious Life Events Increase the Risk of Diabetes-Related Autoimmunity in Their Children. Hospitalization because of diabetes and bereavement: a national cohort study of parents who lost a child. A human beta-cell line for transplantation therapy to control type 1 diabetes. See also Human Beta-cell Line Offers Hope for Type 1 Diabetes Breakthrough, ‘Reversibly immortalized’ cell line that can supply large amounts of insulin-producing human beta-cells, Plans to develop a “universal beta-cell line” – treatment for type 1 diabetes, and Good-bye Insulin Shots. Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing […]

Are there advantages with U-Albumin/U-Creatinine ratios compared with U-Albumin in monitoring diabetes? Increased Plasma Pro-B-Type Natriuretic Peptide in Infants of Women with Type 1 Diabetes. In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice. Glucagon-Like Peptide-1 as a Treatment Option for Type 2 Diabetes and Its Role in Restoring Beta-Cell Mass. Immunomodulation with human recombinant autoantigens. Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes. Gene therapy for diabetes mellitus in rats by intramuscular […]

Up-regulation Of Advanced-glycated Products Receptors In The Brain Of Diabetic Rats Is Prevented By Antioxidant Treatment. Free full text available in PDF format. Use of Long-Term Microdialysis Subcutaneous Glucose Monitoring in the Management of Neonatal Diabetes. Gluatamic Acid Decarboxylase Autoantibody Prevalence and Association with HLA Genotype in Patients with Younger-Onset Type 1 Diabetes and Proliferative Diabetic Retinopathy. Insulin – a primary autoantigen in type 1 diabetes? The pancreatic islet endothelial cell: Emerging roles in islet function and disease. Morphological and functional changes in the diabetic peripheral nerve: using diagnostic ultrasound and neurosensory testing to select candidates for nerve decompression. Surgical […]

Early Nutrition and its later Consequences is a 256-page downloadable PDF with several articles related to nutrition and diabetes, including Trial To Reduce IDDM In The Genetically At Risk (Nutritional Primary Prevention Of Type 1 Diabetes) Early Nutrition And Later Diabetes Risk (page 142), Is Type 1 Diabetes A Disease Of The Gut Immune System Triggered By Cow’s Milk Insulin? (page 151), Gluten-free Diet In Subjects At Risk For Type 1 Diabetes: A Tool For Delaying Progression To Clinical Disease? (page 157), and Dietary Compliance In Diabetes Prevention Project In Finland (page 189). Be patient while the large PDF downloads. […]

The November 2005 issue of Diabetes, Obesity and Metabolism has five articles on the topic of unlocking the opportunity of tight glycaemic control, focusing primarily on the potential for inhaled insulin to achieve better results. Unlocking the opportunity of tight glycaemic control: Far from goal. Unlocking the opportunity of tight glycaemic control: Innovative delivery of insulin via the lung. Unlocking the opportunity of tight glycaemic control: Inhaled insulin: clinical efficacy. Unlocking the opportunity of tight glycaemic control: Inhaled insulin: safety. Unlocking the opportunity of tight glycaemic control: Promise ahead: the role of inhaled insulin in clinical practice. The rising incidence […]

Strict Glycemic Control Slashes CVD Risk in Type 1 Diabetes. The Effect of Insulin Antibodies on the Metabolic Action of Inhaled and Subcutaneous Insulin. What are disease perceptions and subjective treatment goals of insulin treated diabetic patients? Free full text available in PDF format. Where is the Cure? UCSF drug continues to fend off progression of type 1 diabetes. Prevalence of Type 1 diabetes in New Zealanders aged 0-24 years. Identifying risk of type 1 diabetes. How to make pancreatic beta cells – prospects for cell therapy in diabetes. Gastrointestinal stem cells. I. Pancreatic stem cells. Differentiation of Human Liver-Derived, […]

Are children with type 1 diabetes immunocompromised? Also available in PDF format. Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. Free full text available in PDF format. Familial clustering of beta-cell autoimmunity in initially non-diabetic children. Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates. Trying To Predict the Future for People with Diabetes: A Tough but Important Task. Clinical Outcomes and Cost-Effectiveness of Strategies for Managing People at High Risk for Diabetes. Type 2 Diabetes: Problems in the Furnace. DNA vaccination with an insulin construct and a chimeric protein binding to both […]

Circulating acylated and total ghrelin and galanin in children with insulin-treated type 1 diabetes: relationship to insulin therapy, metabolic control and pubertal development. Therapeutic targets for the prevention of type 1 diabetes mellitus. Islet transplantation in type I diabetes mellitus. Estimation of lipoperoxidative damage and antioxidant status in diabetic children: Relationship with individual antioxidants. The DIabetic REtinopathy Candesartan Trials (DIRECT) Programme: baseline characteristics. Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies. HLA DR/DQ alleles and risk of type I diabetes in […]