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December 10, 2006

Central Obesity, Incident Microalbuminuria, and Change in Creatinine Clearance in the Epidemiology of Diabetes Interventions and Complications Study concludes that “… waist circumference predicts the subsequent development of microalbuminuria in type 1 diabetes.”
Predicting the Development of Macrovascular Disease in People with Type 1 Diabetes: A 9-Year Follow-up Study.
Cardiovascular Risk Factors Predicting the Development of Distal Symmetrical Polyneuropathy in People with Type 1 Diabetes: A 9-Year Follow-up Study.
Diabetic Neuropathy Differs in Type 1 and Type 2 Diabetes.
Pancreatic autoantibodies in Italian patients with newly diagnosed type 1 diabetes mellitus over the age of 20 years.
Inflammatory Process in Type 2 Diabetes: The Role of Cytokines.
A Potent Immunomodulatory Compound, VGX-1027, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice.
Research Yields New Insights Into The Cause Of Diabetes.

December 3, 2006

Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes.
Continuous glucose monitoring and external insulin pump: towards a subcutaneous closed loop.
The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.
Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo.
Protection from type 1 diabetes by vitamin d receptor haplotypes.
Immunointervention in newly diagnosed type 1 diabetes.
DiaPep277(R) Preserves Endogenous Insulin Production by Immunomodulation in Type 1 Diabetes.
HLA Class I Epitope Discovery in Type 1 Diabetes.
Effects of Autoimmunity and Immune Therapy on �-Cell Turnover in Type 1 Diabetes.
Is it dietary insulin?
Viruses cause type 1 diabetes in animals.
Immunomodulation for the Prevention of SPIDDM and LADA.
Insulin Treatment in Patients With Type 1 Diabetes Induces Upregulation of Regulatory T-Cell Markers in Peripheral Blood Mononuclear Cells Stimulated With Insulin In Vitro.
Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome.
Early Involvement of the Spinal Cord in Diabetic Peripheral Neuropathy.
Skin Autofluorescence as a Noninvasive Marker of Vascular Damage in Patients With Type 2 Diabetes.
C-Peptide Reverses Nociceptive Neuropathy in Type 1 Diabetes.
Cord Blood Islet Autoantibodies Are Related to Stress in the Mother during Pregnancy.
Recovery of Islet �-Cell Function in Streptozotocin- Induced Diabetic Mice; An Indirect Role for the Spleen.
Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction.
Plasma C-Peptide and Cognitive Performance in Older Men Without Diabetes.

November 26, 2006

New data from NIH lab confirms protocol to reverse type 1 diabetes in mice. However, see also Comment on Papers by Chong et al., Nishio et al., and Suri et al. on Diabetes Reversal in NOD Mice (PDF), Response to Comment on Chong et al. on Diabetes Reversal in NOD Mice (PDF), Response to Comment on Nishio et al. on Diabetes Reversal in NOD Mice (PDF), and Response to Comment on Suri et al. on Diabetes Reversal in NOD Mice (PDF).
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Free full text available in PDF format. See also Human Bone Marrow Cells Repair Mouse Islets.
Elevated serum alanine transaminase in patients with type 1 or type 2 diabetes mellitus.
Elevated circulating adiponectin in type 1 diabetes is associated with long diabetes duration.
Plasma homocysteine, oxidative stress and endothelial function in patients with Type 1 diabetes mellitus and microalbuminuria.
Divergent trends in the incidence of end-stage renal disease due to Type 1 and Type 2 diabetes in Europe, Canada and Australia during 1998-2002.
Pasteur-Weizmann/Servier prize winners advance diabetes therapy R&D.
Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study.
Treatment of new-onset type 1 diabetes with peptide DiaPep277(R) is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial.
Suppression of diabetes in non-obese diabetic (NOD) mice by oral administration of a cholera toxin B subunit-insulin B chain fusion protein vaccine produced in silkworm.
Renoprotective effects of tea catechin in streptozotocin-induced diabetic rats.
Luminance and chromatic visual evoked potentials in type I and type II diabetes: relationships with peripheral neuropathy.

November 19, 2006

Evidence for immunological priming and increased frequency of CD4(+) CD25(+) cord blood T cells in children born to mothers with type 1 diabetes.
Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials.
Viral infections as potential triggers of type 1 diabetes.
Diabetes mellitus and dementia.

November 12, 2006

QT(c) interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up.
Parental reactions to information about increased genetic risk of type 1 diabetes mellitus in infants.
Seasonality of birth in children and young adults (0-29 years) with type 1 diabetes in Ukraine.
The immunity during the pre-clinical period of type I diabetes mellitus.
Patterns of growth among children who later develop type 2 diabetes or its risk factors.
Association of amino-terminal-specific anti-glutamate decarboxylase (GAD65) autoantibodies with beta cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis prone diabetes mellitus. Free full text available in PDF format.

November 5, 2006

Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS).
Maternal understanding of infant diabetes risk: Differential effects of maternal anxiety and depression.
Metabolic factors affecting residual Beta cell function assessed by C-Peptide secretion in patients with newly diagnosed type 1 diabetes.
Markers of absorption and synthesis of cholesterol in men with type 1 diabetes.
Glucose-monitoring with continuous subcutaneous microdialysis in neonatal diabetes mellitus.
Fuzzy-based controller for glucose regulation in type-1 diabetic patients by subcutaneous route.
Partial versus Full Allogeneic Hemopoietic Chimerization Is a Preferential Means to Inhibit Type 1 Diabetes as the Latter Induces Generalized Immunosuppression.

October 29, 2006

Does Coffee Consumption Reduce the Risk of Type 2 Diabetes in Individuals With Impaired Glucose?
Incidence of Type 1 Diabetes in Philadelphia Is Higher in Black Than White Children From 1995 to 1999 – Epidemic or misclassification?
Islet Autoimmunity in Children With Down�s Syndrome.
Evaluation of a New Measure of Blood Glucose Variability in Diabetes.
A multinational assessment of complications in type 1 diabetes: the DiaMond substudy of complications (DiaComp) level 1.
Electrogastrography in children and adolescents with type 1 diabetes: Weak correlation with metabolic control parameters.
Relationship between adiponectin levels, acylated ghrelin levels, and short-term body mass index changes in children with diabetes mellitus type 1 at diagnosis and after insulin therapy.
Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers.
Health Care Use and Costs in the Decade After Identification of Type 1 and Type 2 Diabetes.

October 22, 2006

Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).
Putting the pieces of the puzzle together – a series of hypotheses on the etiology and pathogenesis of type 1 diabetes.
A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease.
Islet antibodies associated with pancreatic B-cell dysfunction at and 3 years after diagnosis of diabetes in subjects aged 35�64 years old: degree of impairment less severe than in those aged 0�34 years old.
Usefulness of colour tissue Doppler imaging in assessing aortic elastic properties in Type 1 diabetic patients.
Mother to child transmission of diabetes mellitus: does gestational diabetes program Type 2 diabetes in the next generation?
Postchallenge glucose rises with increasing age even when glucose tolerance is normal.

October 15, 2006

Advances and Emerging Opportunities in Type 1 Diabetes Research will guide NIH research into type 1 diabetes. See also Plan Will Guide NIH Research in Type 1 Diabetes.
Increased intestinal permeability precedes clinical onset of type 1 diabetes.
Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus.
Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes.
Attitudes of genetic counselors towards expanding newborn screening and offering predictive genetic testing to children.
Prevalence of Glutamic Acid Decarboxylase Antibody Positivity and its Association with Insulin Secretion and Sensitivity in Autoimmune Thyroid Disease: A Pilot Study.
Five Weeks of Treatment with the GLP-1 Analogue Liraglutide Improves Glycaemic Control and Lowers Body weight in Subjects with Type 2 Diabetes.
Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis.

October 8, 2006

The Burden of Diabetes Mellitus Among US Youth: Prevalence Estimates From the SEARCH for Diabetes in Youth Study. See also Study Finds One in 523 Children and Adolescents Have Diabetes.
ABC News has two online videos about the recent study published in The New England Journal of Medicine (International Trial of the Edmonton Protocol for Islet Transplantation): Summary of the Study and Interview with Dr. Camillo Ricordi from the DRI.
Therapy with the hsp60 peptide DiaPep277(TM) in C-peptide positive type 1 diabetes patients. See also The Swedish GAD-vaccination Trial: Outcomes of a Phase II Safety and Efficacy Trial with Diamyd(TM) for Preservation of Beta Cell Function in Children with Type 1 Diabetes.
Dietary insulin as an immunogen and tolerogen.
Is affluence a risk factor for bronchial asthma and type 1 diabetes?
Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives.
Role of seasonal factors in pre- and postnatal ontogenesis for etiology of type 1 diabetes mellitus.
Short-term suppression of elevated growth hormone concentrations following insulin-like growth factor 1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates.
Is arterial hyepertension a significant problem in children and adolescents with type 1 diabetes?
Diabetes mellitus and risk of bladder cancer: a meta-analysis.
Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q.
Beverage Intake Among Preschool Children and Its Effect on Weight Status. Free full text available in HTML and PDF formats.

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