Lg Cwd
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December 19, 2009

Insulin

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Question from India:

Can long acting insulins cause downregulation of insulin’s receptors due to their prolonged and continual exposure in comparison to short acting insulin due to decreased insulin oscillations and degradation?

Answer:

From: DTeam Staff

Theoretically, they could. However, I am no sure that has been worked out. I do not know at what concentration of the analog this becomes a more prominent issue. I do not see increased insulin resistance with insulin glargine compared to NPH.

JTL