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January 30, 2000

Research: Other

Question from South Carolina, USA:

I have a 5 year old son that was diagnosed with type 1 diabetes when he was 5 months old. I have been reading about Pramlintide. I have also heard this would help with digestive problems. I am very interested because my son cries with stomach cramps. Any more information would be appreciated.

Answer:

I do not think that pramlintide [a synthetic analog of the human hormone amylin that is in development] is indicated in a 5 year old. As an adjunct to insulin therapy it has about the same effect as the much less expensive acarbose [Precose, a pill for type 2 diabetes] and neither is as effective in better glucose control as metformin [Glucophage, a different pill for type 2 diabetes].

I sense though that you are really looking for a remedy for his stomach cramps. The most likely cause of this is that up to 10% of Type�1A (autoimmune) diabetics have a form wheat sensitivity which is called the coeliac syndrome. It is a linked autoimmune condition like hypothyroidism and I would talk to the doctor about getting a serum antitransglutaminase antibody test done.

DOB