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February 13, 2000

A1c (Glycohemoglobin, HgbA1c)

Question from Michigan, USA:

If you were to have two different Type 1 individuals with identical blood glucose values over the typical HbA1c time period, is it possible to have vastly varying HbA1c results? In other words, do different body chemistries have the ability to react differently in glucose attachment to hemoglobin?

Answer:

It is unlikely that the Hemoglobin A1c will be vastly different between two individuals with nearly identical blood sugar values if they are testing at frequent intervals during the day. However, understand that blood sugar testing only tells you what your blood sugar is doing at the time of your test. Recent evidence with the glucose sensor shows that blood sugar values are much more variable that we previously thought.

MSB