Question from Dallas, Texas, USA:

My 11 year old daughter, diagnosed at age two, has been on the insulin pump for two years with U-50 Humalog (made with the Lilly diluent). For the last six weeks, she has had a fever of unknown origin (up to 102 degrees F every morning) and is exhausted all day. Her blood sugars have been elevated, which we correct, and she has no ketones. She has had numerous tests and has been on two courses two sets of antibiotics, but the doctors cannot find anything wrong with her. Thinking she might have developed an allergy to Humalog or the diluent, yesterday we changed her to U-100 Novolog, but she still has the fever today. Does it take a while to clean out the system?

She did have a tuberculin test, and her pediatrician doesn’t think she has any infection, but also doesn’t know where else to turn. So, my daughter is seeing an infectious disease specialist next week.

What do you think? Have you heard of people developing allergies to insulin? We are so desperate — six weeks of feeling yucky is awful.